Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA.
Trends Cardiovasc Med. 2012 Apr;22(3):55-61. doi: 10.1016/j.tcm.2012.06.012. Epub 2012 Aug 3.
During the past 100 years, the fruit fly, Drosophila melanogaster, has provided tremendous insights into genetics and human biology. Drosophila-based research utilizes powerful, genetically tractable approaches to identify new genes and pathways that potentially contribute to human diseases. New resources available in the fly research community have advanced the ability to examine genome-wide effects on cardiac function and facilitate the identification of structural, contractile, and signaling molecules that contribute to cardiomyopathies. This powerful model system continues to provide discoveries of novel genes and signaling pathways that are conserved among species and translatable to human pathophysiology.
在过去的 100 年里，黑腹果蝇（Drosophila melanogaster）为遗传学和人类生物学提供了巨大的洞见。基于果蝇的研究利用强大的、可遗传操作的方法来识别可能导致人类疾病的新基因和途径。在果蝇研究社区中可用的新资源提高了检测对心脏功能的全基因组影响的能力，并促进了鉴定导致心肌病的结构、收缩和信号分子的能力。这个强大的模型系统继续提供新基因和信号通路的发现，这些基因和信号通路在物种间保守，并且可以转化为人类病理生理学。
