水飞蓟宾（奶蓟草）可增强雄性小鼠乙醇依赖性肝细胞癌的进展。
Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.
机构信息
Department of Surgery, Carolinas Medical Center, Charlotte, NC 28203, USA.
出版信息
Cancer Lett. 2012 Dec 29;326(1):88-95. doi: 10.1016/j.canlet.2012.07.028. Epub 2012 Aug 1.
Abstract
Hepatocellular carcinoma (HCC) is a global health burden with limited treatment options and poor prognosis. Silibinin, an antioxidant derived from the Milk Thistle plant (Silybum marianum), is reported to exert hepatoprotective and antitumorigenic effects in vitro and in vivo by suppressing oxidative stress and proliferation. Using a DEN-initiated mouse model of HCC, this study examined the effects of dietary silibinin supplementation alone, or in combination with chronic ethanol consumption on HCC progression. Our data demonstrate silibinin exerted marginal hepatoprotective effects in early stages of hepatocarcinogenesis but, when co-administered with ethanol, exacerbated the promotional effects of ethanol in HCC bearing mice, but only in males.
摘要
肝细胞癌 (HCC) 是一种全球性的健康负担，治疗选择有限，预后不良。水飞蓟素是一种从奶蓟草（Silybum marianum）中提取的抗氧化剂，据报道，它通过抑制氧化应激和增殖，在体外和体内发挥保肝和抗肿瘤作用。本研究使用 DEN 诱导的 HCC 小鼠模型，研究了单独或联合补充慢性乙醇摄入对 HCC 进展的影响。我们的数据表明，水飞蓟素在肝癌发生的早期阶段发挥了轻微的保肝作用，但与乙醇联合使用时，会加剧乙醇对 HCC 荷瘤小鼠的促进作用，但仅在雄性小鼠中。
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