Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada.
Schizophr Res. 2012 Oct;141(1):29-34. doi: 10.1016/j.schres.2012.06.042. Epub 2012 Aug 3.
Fibers connecting fronto-temporal and fronto-medial structures that pass through the anterior limb of the internal capsule (ALIC) subserve executive and psychomotor functioning. Both of these functions are adversely affected in schizophrenia, and may be abnormal at illness onset. In a study of first-episode psychosis, we used diffusion tensor imaging (DTI) and cognitive testing to examine ALIC integrity. Fourteen early psychosis patients and 29 healthy volunteers were included. Symptoms were assessed with the Positive and Negative Syndromes Scale (PANSS). All structural and diffusion scans were acquired on a GE Signa 1.5T scanner. A T1-weighted 3D FSPGR Inversion Recovery imaging series was acquired for manual seeding in structural space. Diffusion tensor imaging (DTI) was performed, and all DTI images were co-registered to structural space. Seeds were manually drawn bilaterally on the coronal plane at a specified location. Diffusion images were post-processed for subsequent Tract-based Spatial Statistics (TBSS) analysis. First-episode psychosis patients had significantly smaller fronto-medial and fronto-temporal AIC tract volumes compared to healthy volunteers on the left and the right (p-values<0.04). No differences in mean fractional anisotropy (FA) were seen within either left or right tracts (p-values>0.05), nor did TBSS reveal any other differences in FA values between groups in other regions. Relationships between tract volumes and symptom severity were not observed in this study.
连接额颞叶和额内侧结构的纤维通过内囊前肢（ALIC），这些纤维负责执行和心理运动功能。这两种功能在精神分裂症中都受到影响，并且可能在疾病发作时异常。在一项首发精神病的研究中，我们使用弥散张量成像（DTI）和认知测试来检查 ALIC 的完整性。纳入了 14 名首发精神病患者和 29 名健康志愿者。采用阳性和阴性症状量表（PANSS）评估症状。所有结构和扩散扫描均在 GE Signa 1.5T 扫描仪上进行。采集 T1 加权 3D FSPGR 反转恢复成像序列，用于在结构空间中手动播种。进行弥散张量成像（DTI），并将所有 DTI 图像与结构空间配准。在指定位置的冠状平面上双侧手动绘制种子。对扩散图像进行后处理，以进行随后的基于束的空间统计学（TBSS）分析。与健康志愿者相比，首发精神病患者的左侧和右侧额内侧和额颞叶 AIC 束体积明显较小（p 值<0.04）。在左侧或右侧束内未见平均各向异性分数（FA）的差异（p 值>0.05），TBSS 也未显示两组在其他区域的 FA 值存在任何其他差异。在这项研究中，未观察到束体积与症状严重程度之间的关系。
