Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA.
Int J Tuberc Lung Dis. 2012 Oct;16(10):1405-11. doi: 10.5588/ijtld.12.0054. Epub 2012 Aug 3.
The presence of restrictive lung disease has classically required the measure of total lung capacity to document 'true' restriction, which has limited its detection in large population-based studies.
We used spirometric data to classify people with restricted spirometry (forced expiratory volume in 1 second [FEV(1)]/forced vital capacity ≥ 0.70 and FEV(1) < 80% predicted) in the Burden of Lung Disease (BOLD) Study and determined the relation between this finding and demographic factors and the presence of chronic diseases, including diabetes mellitus, hypertension and cardiovascular disease.
Overall, we found that 11.7% of men (546/4664) and 16.4% of women (836/5098) had restricted spirometry. Prevalence varied widely by site, from a low of 4.2% among males in Sydney, Australia, to a high of 48.7% among females in Manila, The Philippines. Compared to people with normal lung function, those with restricted spirometry had a higher prevalence of diabetes (12.2% vs. 4.6%), heart disease (15.0% vs. 7.7%) and hypertension (38.8% vs. 22.8%).
Restricted spirometry is a common finding in population studies. Additional research is needed to better define and describe the mechanisms that lead to restricted spirometry and potential interventions.
限制性肺疾病的存在传统上需要测量肺总量来证明“真正”的限制，这限制了其在大型基于人群的研究中的检测。
我们使用肺活量测定数据将受限型肺功能障碍（FEV1/FVC≥0.70 且 FEV1<80%预计值）患者在 Burden of Lung Disease（BOLD）研究中分类，并确定这一发现与人口统计学因素和包括糖尿病、高血压和心血管疾病在内的慢性疾病之间的关系。
总体而言，我们发现 11.7%的男性（546/4664）和 16.4%的女性（836/5098）存在受限型肺功能。患病率因地点而异，从澳大利亚悉尼男性的低值 4.2%到菲律宾马尼拉女性的高值 48.7%不等。与肺功能正常的人相比，受限型肺功能患者的糖尿病（12.2% vs. 4.6%）、心脏病（15.0% vs. 7.7%）和高血压（38.8% vs. 22.8%）患病率更高。
受限型肺功能是人群研究中的常见发现。需要进一步研究以更好地定义和描述导致受限型肺功能的机制和潜在干预措施。
