单纯疱疹病毒2型的DNA片段及其在人宫颈癌组织中的转录。
A DNA fragment of Herpes simplex 2 and its transcription in human cervical cancer tissue.
作者信息
Frenkel N, Roizman B, Cassai E, Nahmias A
出版信息
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3784-9. doi: 10.1073/pnas.69.12.3784.
Abstract
A human cervical tumor, free of detectable infectious herpes simplex 2 virus, contained a fragment comprising 39% of herpes viral DNA. Renaturation kinetics indicate that an average of 1 to 3.5 DNA fragments of herpes simplex virus are present per cell, depending on the ploidy of the cells in this particular tumor. Virus-specific sequences were found linked to highly repetitive sequences of host DNA, which reassociated under conditions designed to preclude reassociation of viral sequences. The tumor also contained RNA transcripts complementary to 5% of the viral DNA. The fraction of viral DNA template transcribed in the cervical tumor is considerably less than that transcribed in productively infected cells (50%).
摘要
一个未检测到传染性单纯疱疹病毒2型的人类宫颈肿瘤，含有一段占疱疹病毒DNA 39%的片段。复性动力学表明，根据该特定肿瘤中细胞的倍性，每个细胞平均存在1至3.5个单纯疱疹病毒DNA片段。发现病毒特异性序列与宿主DNA的高度重复序列相连，这些序列在旨在阻止病毒序列复性的条件下重新结合。该肿瘤还含有与5%的病毒DNA互补的RNA转录本。宫颈肿瘤中转录的病毒DNA模板比例远低于在产生性感染细胞中转录的比例（50%）。
相似文献
1
A DNA fragment of Herpes simplex 2 and its transcription in human cervical cancer tissue.单纯疱疹病毒2型的DNA片段及其在人宫颈癌组织中的转录。
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3784-9. doi: 10.1073/pnas.69.12.3784.
2
3
[Herpes virus and cancer of the cervix].[疱疹病毒与宫颈癌]
Union Med Can. 1980 Jan;109(1):103-8.
4
Herpes simplex virus and human cancer. I. Relationship between human cervical tumours and Herpes simplex type 2.单纯疱疹病毒与人类癌症。I. 人类宫颈肿瘤与2型单纯疱疹病毒之间的关系。
Eur J Cancer (1965). 1981 Jun;17(6):685-93. doi: 10.1016/0014-2964(81)90273-5.
5
RNA synthesis in cells infected with herpes simplex virus. VII. Control of transcription and of transcript abundancies of unique and common sequences of herpes simplex virus 1 and 2.感染单纯疱疹病毒的细胞中的RNA合成。VII. 单纯疱疹病毒1型和2型独特及共同序列转录及转录本丰度的调控
J Virol. 1973 Jun;11(6):886-92. doi: 10.1128/JVI.11.6.886-892.1973.
6
Biochemical approaches to detection of herpes simplex virus type 2 in cervical carcinoma.检测宫颈癌中2型单纯疱疹病毒的生化方法。
Cancer Res. 1974 May;34(5):1136-9.
7
In vitro transcription of herpes simplex virus ANG DNA by E-coli RNA polymerase.大肠杆菌RNA聚合酶对单纯疱疹病毒ANG DNA的体外转录
Nucleic Acids Res. 1977 Jun;4(6):1793-802. doi: 10.1093/nar/4.6.1793.
8
Herpesvirus-specific RNA and protein in carcinoma of the uterine cervix.子宫颈癌中的疱疹病毒特异性RNA和蛋白质。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3853-7. doi: 10.1073/pnas.79.12.3853.
9
Nucleic acid hybridization and the relationship between cervical cancer and herpes simplex virus type 2.核酸杂交以及宫颈癌与2型单纯疱疹病毒之间的关系。
Cancer Res. 1973 Jun;33(6):1548-51.
10
[Type 2 Herpes simplex virus and cervical carcinoma].[2型单纯疱疹病毒与宫颈癌]
Zentralbl Bakteriol Orig A. 1974;227(1-4):356-61.
引用本文的文献
1
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications.单纯疱疹病毒、人乳头瘤病毒与宫颈癌：概述、关系及治疗意义
Cancers (Basel). 2023 Jul 20;15(14):3692. doi: 10.3390/cancers15143692.
2
Seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: NHANES (1999-2014).单纯疱疹病毒 2 型血清阳性，但 1 型阴性与宫颈癌相关：NHANES（1999-2014）。
BMC Cancer. 2017 Nov 7;17(1):726. doi: 10.1186/s12885-017-3734-2.
3
Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.直接证据表明，紫外线（UV）照射损伤的单纯疱疹病毒（HSV）DNA 可以在依赖于细胞类型的方式下修复。
J Neurovirol. 2012 Jun;18(3):231-43. doi: 10.1007/s13365-012-0105-2. Epub 2012 May 12.
4
The roles of viruses in brain tumor initiation and oncomodulation.病毒在脑肿瘤发生和致癌调节中的作用。
J Neurooncol. 2011 Dec;105(3):451-66. doi: 10.1007/s11060-011-0658-6. Epub 2011 Jul 1.
5
Stimulation of cellular DNA synthesis by human cytomegalovirus.人巨细胞病毒对细胞DNA合成的刺激作用。
J Virol. 1974 Feb;13(2):353-62. doi: 10.1128/JVI.13.2.353-362.1974.
6
Multifactorial etiology of cervical cancer: a hypothesis.宫颈癌的多因素病因：一种假说。
MedGenMed. 2005 Nov 30;7(4):57.
7
Genital herpes simplex.单纯性生殖器疱疹
Can Med Assoc J. 1981 Jul 1;125(1):23-9.
8
Detection of herpes simplex virus type-2 DNA restriction fragments in human cervical carcinoma tissue.人宫颈癌组织中单纯疱疹病毒2型DNA限制性片段的检测
EMBO J. 1983;2(7):1029-34. doi: 10.1002/j.1460-2075.1983.tb01541.x.
9
Herpesvirus-specific RNA and protein in carcinoma of the uterine cervix.子宫颈癌中的疱疹病毒特异性RNA和蛋白质。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3853-7. doi: 10.1073/pnas.79.12.3853.
10
Comparative studies of transformed hamster cells by Herpesvirus hominis types 1 and 2.人疱疹病毒1型和2型对仓鼠细胞转化的比较研究。
Br J Exp Pathol. 1982 Jun;63(3):285-98.
本文引用的文献
1
METAPHASE CHROMOSOMES AS A SOURCE OF DNA.中期染色体作为DNA的来源。
Biochim Biophys Acta. 1964 Dec 16;91:691-4. doi: 10.1016/0926-6550(64)90032-5.
2
3
The association of herpesvirus type 2 and carcinoma of the uterine cervix.2型疱疹病毒与子宫颈癌的关联。
Am J Epidemiol. 1969 May;89(5):547-54. doi: 10.1093/oxfordjournals.aje.a120967.
4
Kinetics of renaturation of DNA.DNA复性动力学
J Mol Biol. 1968 Feb 14;31(3):349-70. doi: 10.1016/0022-2836(68)90414-2.
5
A polynucleotide segment rich in adenylic acid in the rapidly-labeled polyribosomal RNA component of mouse sarcoma 180 ascites cells.在小鼠肉瘤180腹水细胞快速标记的多核糖体RNA组分中富含腺苷酸的多核苷酸片段。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1331-5. doi: 10.1073/pnas.68.6.1331.
6
Populations of repeated DNA sequences in the human genome.人类基因组中重复DNA序列群体。
J Mol Biol. 1972 Feb 14;63(3):323-34. doi: 10.1016/0022-2836(72)90430-5.
7
Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance.感染单纯疱疹病毒的细胞中的核糖核酸合成：转录及RNA丰度的调控
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2654-8. doi: 10.1073/pnas.69.9.2654.
8
Genetic relatedness of type 1 and type 2 herpes simplex viruses.1型和2型单纯疱疹病毒的遗传相关性。
J Virol. 1972 May;9(5):738-45. doi: 10.1128/JVI.9.5.738-745.1972.
9
Herpes vimplex virus: genome size and redundancy studied by renaturation kinetics.单纯疱疹病毒：通过复性动力学研究基因组大小和冗余度。
J Virol. 1971 Oct;8(4):591-3. doi: 10.1128/JVI.8.4.591-593.1971.
10
Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.单纯疱疹病毒1型和2型脱氧核糖核酸的大小、组成及结构
J Virol. 1971 Aug;8(2):125-32. doi: 10.1128/JVI.8.2.125-132.1971.
Zotero 插件