Sjödin B, Hellsten Westing Y
Swedish Defense Research Establishment, Stockholm.
Int J Sports Med. 1990 Dec;11(6):493-5. doi: 10.1055/s-2007-1024844.
The relationship between running intensity and the accumulation of hypoxanthine and uric acid in plasma was studied in four well-trained runners. The runners each performed several 800-m runs at different velocities, each run being performed on separate days. Venous blood samples were collected before and at regular intervals after the runs. The concentration of hypoxanthine and uric acid was determined with high performance liquid chromatography (HPLC) in plasma extracts. A marked increase in the plasma concentration of both hypoxanthine and uric acid occurred simultaneously at intensities corresponding to 110, 108, 115 and 107% of VO2max for subject a, b, c and d, respectively. The sudden sharp increase in plasma concentration of hypoxanthine and uric acid may indicate that at a certain level of running intensity ATP catabolism exceeds the rate of ATP regeneration from the normal metabolic pathways.
在四名训练有素的跑步者中研究了跑步强度与血浆中次黄嘌呤和尿酸积累之间的关系。这些跑步者每人以不同速度进行了几次800米跑，每次跑步在不同日期进行。在跑步前和跑步后定期采集静脉血样。用高效液相色谱法（HPLC）测定血浆提取物中次黄嘌呤和尿酸的浓度。对于受试者a、b、c和d，次黄嘌呤和尿酸的血浆浓度分别在相当于最大摄氧量（VO2max）的110%、108%、115%和107%的强度下同时出现显著增加。次黄嘌呤和尿酸血浆浓度的突然急剧增加可能表明，在一定的跑步强度水平下，ATP分解代谢超过了正常代谢途径中ATP再生的速率。
