Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Eur J Immunol. 2012 Aug;42(8):1977-80. doi: 10.1002/eji.201242755.
Follicular T-helper (T(FH) ) cells are a subset of CD4(+) T cells that is specialized to help B cells. Their capacity to give rise to enhanced T(FH) memory responses has not been documented. A study by Weber et al. [Eur. J. Immunol. 2012 42: 1981-1988] in this issue of the European Journal of Immunology addresses this question, and a picture is emerging from this and several other recent studies which suggests that the formation of memory T(FH) and of central memory (T(CM) ) cells are intimately bound and that the heterogeneity of what we currently call "T(FH) '' cells clouds this issue. In this Commentary, we discuss these complexities and ask what memory T(FH) cells are doing given that the germinal centers are a feature of primary, but not secondary immune responses.
滤泡辅助性 T 细胞（T(FH)）是一类特异性辅助 B 细胞的 CD4(+) T 细胞亚群。它们产生增强型 T(FH)记忆应答的能力尚未被记录。Weber 等人在本期《欧洲免疫学杂志》上的研究[Eur. J. Immunol. 2012 42: 1981-1988]探讨了这个问题，并且这一研究以及其他一些最近的研究表明，记忆 T(FH)和中央记忆（T(CM)）细胞的形成密切相关，我们目前所谓的“T(FH) ”细胞的异质性使得这个问题复杂化。在这篇评论中，我们讨论了这些复杂性，并提出了一个问题，即鉴于生发中心是初次免疫反应的特征，而不是二次免疫反应的特征，那么记忆 T(FH)细胞在做什么。
