Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1-dong, Dong-gu, Gwangju, Korea.
Gastric Cancer. 2013 Apr;16(2):254-60. doi: 10.1007/s10120-012-0176-z. Epub 2012 Aug 3.
Although previous studies have demonstrated an association between ABO blood group and the risk of gastric cancer (GC), only one study has identified these associations using the ABO genotype; however, that study did not evaluate sex differences in this association. The aim of the present study was to investigate whether there are sex-specific differences in the ABO genotype-associated risk of GC. In addition, we explored the association of the ABO genotype and the clinicopathologic characteristics of GC in a Korean population.
We conducted a large-scale case-control study of 3245 GC patients (2204 males, 1041 females) and 1700 controls (821 males, 879 females). The ABO genotype was determined by multicolor real-time polymerase chain reaction (PCR) using displacing probes.
As compared with genotype OO, genotypes AA and AO in females, but not in males, were associated with a significantly increased risk of GC (odds ratio [OR] 1.56 and 95 % confidence interval [CI] 1.08-2.26 for AA; OR 1.57 and 95 % CI 1.21-2.03 for AO). In a subgroup analysis, blood group A had a significantly increased risk of diffuse-type GC (OR 2.00, 95 % CI 1.43-2.78), but not of intestinal-type (OR 1.31, 95 % CI 0.96-1.79) or mixed-type GC (OR 1.43, 95 % CI 0.92-2.24).
The ABO genotypes AA and AO were significantly associated with GC only in females and only for diffuse-type GC. These data suggest that the association between ABO blood group and GC risk may differ according to sex and histological type.
尽管先前的研究已经表明 ABO 血型与胃癌（GC）风险之间存在关联，但仅有一项研究使用 ABO 基因型来确定这些关联；然而，该研究并未评估这种关联在性别方面的差异。本研究旨在探讨 ABO 基因型相关 GC 风险是否存在性别特异性差异。此外，我们还探讨了 ABO 基因型与韩国人群 GC 的临床病理特征之间的关联。
我们进行了一项大规模的病例对照研究，纳入了 3245 名 GC 患者（2204 名男性，1041 名女性）和 1700 名对照（821 名男性，879 名女性）。使用双色实时聚合酶链反应（PCR）结合置换探针确定 ABO 基因型。
与基因型 OO 相比，女性而非男性的基因型 AA 和 AO 与 GC 风险显著增加相关（AA 的比值比 [OR] 为 1.56，95%置信区间 [CI] 为 1.08-2.26；AO 的 OR 为 1.57，95%CI 为 1.21-2.03）。在亚组分析中，血型 A 与弥漫型 GC 的风险显著增加相关（OR 为 2.00，95%CI 为 1.43-2.78），但与肠型（OR 为 1.31，95%CI 为 0.96-1.79）或混合型 GC（OR 为 1.43，95%CI 为 0.92-2.24）无关。
仅在女性和弥漫型 GC 中，ABO 基因型 AA 和 AO 与 GC 显著相关。这些数据表明，ABO 血型与 GC 风险之间的关联可能因性别和组织学类型而异。
