Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7420, USA.
Stat Med. 2012 Oct 30;31(24):2872-81. doi: 10.1002/sim.5365. Epub 2012 Aug 1.
We propose a Bayesian adaptive two-stage design for the efficient estimation of the maximum dose or the minimum effective dose in a dose-finding trial. The new design allocates subjects in stage two according to the posterior distribution of the target dose location. Simulations show that the proposed two-stage design is superior to equal allocation and to a two-stage strategy where only one dose is left in the second stage.
我们提出了一种贝叶斯自适应两阶段设计，用于在探索性试验中高效估计最大剂量或最小有效剂量。新设计根据目标剂量位置的后验分布在第二阶段分配受试者。模拟结果表明，所提出的两阶段设计优于均等分配和第二阶段仅留一个剂量的两阶段策略。
