Boder Jamela Mostafa E, Elmabrouk Abdalla Fathi B, Elfageih Mohamed Ahmed, Abusaa Abuagela, Buhmeida Abdelbaset, Collan Yrjö
Department of Pathology, University of Turku, Turku, Finland.
Oncol Lett. 2011 Mar;2(2):323-330. doi: 10.3892/ol.2011.245. Epub 2011 Jan 20.
The present study evaluated the incidence of breast cancer in Libya and described the clinicopathological and demographic features. These features were then compared with corresponding data from patients from sub-Saharan Africa (Nigeria) and Europe (Finland). The study consisted of 234 patients with breast carcinoma, admitted to the African Oncology Institute in Sabratha, Libya, during the years 2002-2006. The pathological features were collected from pathology reports, patient histories from hospital files and the Sabratha Cancer Registry. The demographic differences between the Libyan, Nigerian and Finnish populations were prominent. The mean age of breast cancer patients in Libya was 46 years which was almost identical to that of Nigeria, but much lower than that of Finland. The Libyan breast cancer incidence was evaluated as 18.8 per 100,000 female individuals. This incidence was markedly higher in Finland, but was also high in Nigeria. Libyan and Nigerian breast cancer is predominantly of premenopausal type and exhibits unfavorable characteristics such as high histological grade and stage, large tumor size and frequent lymph node metastases. However, the histological types and histopathological risk features show similar importance regarding survival as European breast cancer cases. Survival in Libya ranks between the rates of survival in Nigeria (lowest) and Finland (highest). In conclusion, in Libya and other African countries, premenopausal breast cancer is more common than postmenopausal breast cancer. However, the opposite is true for Europe. Population differences may be involved, as suggested by the known variation, in the distribution of genetic markers in these populations. Different types of environmental impacts, however, cannot be excluded.
本研究评估了利比亚乳腺癌的发病率，并描述了其临床病理特征和人口统计学特征。然后将这些特征与来自撒哈拉以南非洲（尼日利亚）和欧洲（芬兰）患者的相应数据进行比较。该研究纳入了2002年至2006年期间入住利比亚萨卜拉塔非洲肿瘤研究所的234例乳腺癌患者。病理特征从病理报告中收集，患者病史从医院档案和萨卜拉塔癌症登记处获取。利比亚、尼日利亚和芬兰人群之间的人口统计学差异显著。利比亚乳腺癌患者的平均年龄为46岁，与尼日利亚几乎相同，但远低于芬兰。利比亚乳腺癌发病率评估为每10万名女性中有18.8例。芬兰的这一发病率明显更高，但尼日利亚也很高。利比亚和尼日利亚的乳腺癌主要为绝经前类型，具有不利特征，如组织学分级和分期高、肿瘤体积大以及频繁的淋巴结转移。然而，组织学类型和组织病理学风险特征在生存方面与欧洲乳腺癌病例显示出相似的重要性。利比亚的生存率介于尼日利亚（最低）和芬兰（最高）之间。总之，在利比亚和其他非洲国家，绝经前乳腺癌比绝经后乳腺癌更常见。然而，欧洲的情况则相反。如这些人群中已知的遗传标记分布差异所表明的，可能涉及人群差异。然而，不同类型的环境影响也不能排除。
