PGC7、H3K9me2 和 Tet3：受精卵中 DNA 甲基化的调控因子。
PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes.
机构信息
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
出版信息
Cell Res. 2013 Jan;23(1):6-9. doi: 10.1038/cr.2012.117. Epub 2012 Aug 7.
Abstract
In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-methylcytosine. The adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Nakamura et al. recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.
摘要
在受精卵中，在第一次细胞分裂之前，DNA 甲基化在父本原核中选择性地丢失，同时出现 5-甲基胞嘧啶的修饰形式。相邻的母本原核和某些父本印记基因座受到这种过程的保护。Nakamura 等人最近阐明了涉及的分子机制：PGC7/Stella/Dppa3 与二甲基化组蛋白 3 赖氨酸 9（H3K9me2）结合，从而阻断母体基因组中 Tet3 甲基胞嘧啶氧化酶的活性，以及父本基因组中某些印记基因座的活性。
相似文献
1
PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes.PGC7、H3K9me2 和 Tet3：受精卵中 DNA 甲基化的调控因子。
Cell Res. 2013 Jan;23(1):6-9. doi: 10.1038/cr.2012.117. Epub 2012 Aug 7.
2
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.PGC7 通过结合组蛋白 H3K9me2 来防止早期胚胎中 5mC 向 5hmC 的转化。
Nature. 2012 Jun 3;486(7403):415-9. doi: 10.1038/nature11093.
3
H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine.H3K9me2 将 PGC7 吸引到受精卵中，以防止 Tet3 介导的 5-甲基胞嘧啶氧化。
J Mol Cell Biol. 2012 Dec;4(6):427-9. doi: 10.1093/jmcb/mjs038. Epub 2012 Jun 29.
4
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.哺乳动物受精卵中的 5-羟甲基胞嘧啶与表观遗传重编程有关。
Nat Commun. 2011;2:241. doi: 10.1038/ncomms1240.
5
Dimethylated histone H3 lysine 9 is dispensable for the interaction between developmental pluripotency-associated protein 3 (Dppa3) and ten-eleven translocation 3 (Tet3) in somatic cells.二甲基化组蛋白H3赖氨酸9对于体细胞中发育多能性相关蛋白3（Dppa3）与十一易位蛋白3（Tet3）之间的相互作用是可有可无的。
Reprod Fertil Dev. 2019 Jan;31(2):347-356. doi: 10.1071/RD18062.
6
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.斯特拉通过抑制5-羟甲基胞嘧啶（5hmC）诱导的γH2AX积累来维持母源染色体的完整性。
EMBO Rep. 2015 May;16(5):582-9. doi: 10.15252/embr.201439427. Epub 2015 Feb 17.
7
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.Tet3 DNA 双加氧酶在卵母细胞表观遗传重编程中的作用。
Nature. 2011 Sep 4;477(7366):606-10. doi: 10.1038/nature10443.
8
Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.DPPA3 的细胞质裂解对于小鼠的细胞内运输和卵裂期发育是必需的。
Nat Commun. 2017 Nov 21;8(1):1643. doi: 10.1038/s41467-017-01387-6.
9
Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.母体TET3对胚胎发育并非必需，但对新生儿生长却是必需的。
Sci Rep. 2015 Oct 28;5:15876. doi: 10.1038/srep15876.
10
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes.Tet3和DNA复制介导小鼠受精卵中母本和父本基因组的去甲基化。
Cell Stem Cell. 2014 Oct 2;15(4):459-471. doi: 10.1016/j.stem.2014.09.002.
引用本文的文献
1
TET3 regulates hematopoietic stem cell homeostasis during embryonic and adult hematopoiesis.TET3在胚胎期和成年期造血过程中调节造血干细胞稳态。
Hemasphere. 2025 May 6;9(5):e70140. doi: 10.1002/hem3.70140. eCollection 2025 May.
2
PGC7 regulates maternal mRNA translation via AKT1-YBX1 interactions in mouse oocytes.PGC7通过小鼠卵母细胞中的AKT1 - YBX1相互作用调节母体mRNA翻译。
Cell Commun Signal. 2024 Dec 18;22(1):604. doi: 10.1186/s12964-024-01976-1.
3
Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification.TET3 在神经外胚层特化过程中特定遗传程序调控中的催化依赖性和非依赖性作用。
Commun Biol. 2024 Apr 5;7(1):415. doi: 10.1038/s42003-024-06120-w.
4
Dppa3 Improves the Germline Competence of Pluripotent Stem Cells.Dppa3 可提高多能干细胞的生殖系能力。
Stem Cell Rev Rep. 2023 Aug;19(6):1845-1855. doi: 10.1007/s12015-023-10552-y. Epub 2023 May 12.
5
Dppa3 facilitates self-renewal of embryonic stem cells by stabilization of pluripotent factors.Dppa3通过稳定多能性因子促进胚胎干细胞的自我更新。
Stem Cell Res Ther. 2022 Apr 27;13(1):169. doi: 10.1186/s13287-022-02846-8.
6
Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming.催化抑制 H3K9me2 写入物会在牛核重编程过程中扰乱表观遗传标记。
Sci Rep. 2020 Jul 13;10(1):11493. doi: 10.1038/s41598-020-67733-9.
7
The Vast Complexity of the Epigenetic Landscape during Neurodevelopment: An Open Frame to Understanding Brain Function.神经发育过程中表观遗传学景观的复杂性：理解大脑功能的开放框架。
Int J Mol Sci. 2018 May 1;19(5):1333. doi: 10.3390/ijms19051333.
8
Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.暴露于肠道微生物群会导致出生后肠道上皮细胞的甲基组和转录组发生明显变化。
Genome Med. 2018 Apr 13;10(1):27. doi: 10.1186/s13073-018-0534-5.
9
Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes.母鼠肥胖导致的胚胎缺陷源于卵母细胞中 Stella 的不足。
Nat Genet. 2018 Mar;50(3):432-442. doi: 10.1038/s41588-018-0055-6. Epub 2018 Feb 19.
10
Effect of TET inhibitor on bovine parthenogenetic embryo development.TET 抑制剂对牛孤雌生殖胚胎发育的影响。
PLoS One. 2017 Dec 21;12(12):e0189542. doi: 10.1371/journal.pone.0189542. eCollection 2017.
本文引用的文献
1
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.PGC7 通过结合组蛋白 H3K9me2 来防止早期胚胎中 5mC 向 5hmC 的转化。
Nature. 2012 Jun 3;486(7403):415-9. doi: 10.1038/nature11093.
2
Parallel mechanisms of epigenetic reprogramming in the germline.生殖系中表观遗传重编程的平行机制。
Trends Genet. 2012 Apr;28(4):164-74. doi: 10.1016/j.tig.2012.01.005. Epub 2012 Mar 3.
3
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.Tet 介导的哺乳动物 DNA 中 5-羧基胞嘧啶的形成及其由 TDG 切除。
Science. 2011 Sep 2;333(6047):1303-7. doi: 10.1126/science.1210944. Epub 2011 Aug 4.
4
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.Tet 蛋白可以将 5-甲基胞嘧啶转化为 5-醛基胞嘧啶和 5-羧基胞嘧啶。
Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21.
5
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.哺乳动物受精卵中的 5-羟甲基胞嘧啶与表观遗传重编程有关。
Nat Commun. 2011;2:241. doi: 10.1038/ncomms1240.
6
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.受精时父本基因组的重编程涉及到 5-甲基胞嘧啶的全基因组氧化。
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3642-7. doi: 10.1073/pnas.1014033108. Epub 2011 Feb 14.
7
Mammalian cytosine methylation at a glance.哺乳动物胞嘧啶甲基化概述。
J Cell Sci. 2009 Aug 15;122(Pt 16):2787-91. doi: 10.1242/jcs.015123.
8
Distinctive chromatin in human sperm packages genes for embryo development.人类精子中独特的染色质包装着用于胚胎发育的基因。
Nature. 2009 Jul 23;460(7254):473-8. doi: 10.1038/nature08162. Epub 2009 Jun 14.
9
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids.参与核酸碱基氧化及其他复杂修饰的新型酶家族的预测。
Cell Cycle. 2009 Jun 1;8(11):1698-710. doi: 10.4161/cc.8.11.8580. Epub 2009 Jun 27.
10
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.MLL 蛋白伴侣 TET1 将哺乳动物 DNA 中的 5-甲基胞嘧啶转化为 5-羟甲基胞嘧啶。
Science. 2009 May 15;324(5929):930-5. doi: 10.1126/science.1170116. Epub 2009 Apr 16.
Zotero 插件