La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Cell Res. 2013 Jan;23(1):6-9. doi: 10.1038/cr.2012.117. Epub 2012 Aug 7.
In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-methylcytosine. The adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Nakamura et al. recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.
在受精卵中，在第一次细胞分裂之前，DNA 甲基化在父本原核中选择性地丢失，同时出现 5-甲基胞嘧啶的修饰形式。相邻的母本原核和某些父本印记基因座受到这种过程的保护。Nakamura 等人最近阐明了涉及的分子机制：PGC7/Stella/Dppa3 与二甲基化组蛋白 3 赖氨酸 9（H3K9me2）结合，从而阻断母体基因组中 Tet3 甲基胞嘧啶氧化酶的活性，以及父本基因组中某些印记基因座的活性。
