Mammalian cytosine methylation at a glance.
作者信息
Ooi Steen K T, O'Donnell Anne H, Bestor Timothy H
机构信息
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA.
出版信息
J Cell Sci. 2009 Aug 15;122(Pt 16):2787-91. doi: 10.1242/jcs.015123.
Abstract
摘要
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本文引用的文献
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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain.核DNA碱基5-羟甲基胞嘧啶存在于浦肯野神经元和大脑中。
Science. 2009 May 15;324(5929):929-30. doi: 10.1126/science.1169786. Epub 2009 Apr 16.
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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.MLL 蛋白伴侣 TET1 将哺乳动物 DNA 中的 5-甲基胞嘧啶转化为 5-羟甲基胞嘧啶。
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Epigenetics in the nervous system.神经系统中的表观遗传学
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A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.由单个转座子引发的piRNA途径与小鼠的DNA从头甲基化有关。
Mol Cell. 2008 Sep 26;31(6):785-99. doi: 10.1016/j.molcel.2008.09.003.
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A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.一种母源-合子效应基因Zfp57可维持母源和父源印记。
Dev Cell. 2008 Oct;15(4):547-57. doi: 10.1016/j.devcel.2008.08.014.
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Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism.SRA蛋白UHRF1通过碱基翻转机制识别半甲基化DNA。
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Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.人UHRF1的SRA结构域识别半甲基化DNA的结构基础。
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The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix.UHRF1的SRA结构域将5-甲基胞嘧啶翻转出DNA螺旋结构。
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