State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, P R China.
Dalton Trans. 2012 Aug 28;41(36):11134-44. doi: 10.1039/c2dt31227a.
In this work, we prepared polyacrylic acid (PAA) coated gold nanorods (GNRs) and then the targeting peptide modified GNRs. The biocompatibility and stability of functionalized GNRs were investigated by monitoring the surface plasmon resonance (SPR) absorption intensity. The efficacy of targeted thermal therapy can be significantly enhanced via decoration with surface-bound peptide which was obtained through phage display technology. In addition, the photothermal therapy was monitored in real time with the multi-channel function of a confocal laser scanning microscope (CLSM) coupled with an 808 nm laser. This selective photothermal therapy of GNRs is a promising candidate for phototherapeutic applications.
在这项工作中，我们制备了聚丙烯酸（PAA）包覆的金纳米棒（GNRs），然后对靶向肽进行了修饰。通过监测表面等离子体共振（SPR）吸收强度，研究了功能化 GNRs 的生物相容性和稳定性。通过利用噬菌体展示技术获得的表面结合肽的修饰，可以显著增强靶向热疗的疗效。此外，通过与 808nm 激光耦合的共聚焦激光扫描显微镜（CLSM）的多通道功能实时监测光热治疗。这种 GNRs 的选择性光热治疗是光疗应用的一种很有前途的候选方法。
