Mao Zhigang, Xiao Weiwei, Wang Haijun, Li Zhi, Huang Quan, He Dongsheng, Zhu Yonghong
Department of Neurosurgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Oncol Lett. 2011 Jan;2(1):37-41. doi: 10.3892/ol.2010.209. Epub 2010 Nov 23.
This report describes two cases of pituicytoma. The two patients were female and presented with visual complaints, diabetes insipidus, headaches and menstrual disorders. The imaging characteristic was an intrasellar or suprasellar mass, and one mass originated in the pituitary stalk. The mass showed homogeneous enhancement with contrast administration. A hematoxylin and eosin stain showed a compact structure consisting of elongated, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern. Immunohistochemically, the tumor showed diffuse strong expression of S-100 protein, vimentin and epithelial membrane antigen, and glial fibrillary acidic protein was focally positive. The pituicytoma may have originated in the pituitary stalk and presented with diabetes insipidus, and the differential diagnosis should be compared with the pituitary stalk mass. Bleeding during resection was moderate, and surgery was regarded as the first choice of treatment for pituicytomas.
本报告描述了两例垂体细胞瘤。两名患者均为女性，表现为视觉障碍、尿崩症、头痛和月经紊乱。影像学特征为鞍内或鞍上肿块，其中一个肿块起源于垂体柄。肿块在注射造影剂后呈均匀强化。苏木精-伊红染色显示由细长的双极梭形细胞组成的致密结构，这些细胞排列成交错的束状或呈席纹状。免疫组化显示，肿瘤弥漫性强表达S-100蛋白、波形蛋白和上皮膜抗原，胶质纤维酸性蛋白局灶性阳性。垂体细胞瘤可能起源于垂体柄并伴有尿崩症，鉴别诊断应与垂体柄肿块相比较。切除术中出血适中，手术被视为垂体细胞瘤的首选治疗方法。
