Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, United States.
Pharmacol Res. 2012 Dec;66(6):463-74. doi: 10.1016/j.phrs.2012.07.003. Epub 2012 Jul 31.
Autophagy is a lysosomal degradation pathway that can degrade bulk cytoplasm and superfluous or damaged organelles, such as mitochondria, to maintain cellular homeostasis. It is now known that dysregulation of autophagy can cause pathogenesis of numerous human diseases. Here, we discuss the critical roles that autophagy plays in the pathogenesis of liver diseases such as non-alcoholic and alcoholic fatty liver, drug-induced liver injury, protein aggregate-related liver diseases, viral hepatitis, fibrosis, aging and liver cancer. In particular, we discuss the emerging therapeutic potential by pharmacological modulation of autophagy for these liver diseases.
自噬是一种溶酶体降解途径，可以降解大量细胞质和多余或受损的细胞器，如线粒体，以维持细胞内的平衡。现在已知，自噬的失调会导致许多人类疾病的发病机制。在这里，我们讨论了自噬在非酒精性和酒精性脂肪肝、药物性肝损伤、蛋白聚集相关性肝病、病毒性肝炎、纤维化、衰老和肝癌等肝脏疾病发病机制中的关键作用。特别是，我们讨论了通过药理学调节自噬治疗这些肝脏疾病的新出现的治疗潜力。
