Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research Orangeburg, NY 10962, USA.
Neuroscience. 2012 Oct 25;223:12-20. doi: 10.1016/j.neuroscience.2012.07.067. Epub 2012 Aug 4.
The entorhinal cortex is a brain area with multiple reciprocal connections to the hippocampus, amygdala, perirhinal cortex, olfactory bulb and piriform cortex. As such, it is thought to play a large role in the olfactory memory process. The present study is the first to compare lateral entorhinal and anterior piriform cortex odor-evoked single-unit and local field potential activity in mouse. Recordings were made in urethane-anesthetized mice that were administered a range of three pure odors and three overlapping odor mixtures. Results show that spontaneous as well as odor-evoked unit activity was lower in lateral entorhinal versus piriform cortex. In addition, units in lateral entorhinal cortex were responsive to a more restricted set of odors compared to piriform. Conversely, odor-evoked power change in local field potential activity was greater in the lateral entorhinal cortex in the theta band than in piriform. The highly odor-specific and restricted firing in lateral entorhinal cortex suggests that it may play a role in modulating odor-specific, experience- and state-dependent olfactory coding.
内嗅皮层是一个与海马体、杏仁核、边缘皮层、嗅球和梨状皮层有多重相互连接的脑区。因此，它被认为在嗅觉记忆过程中起着重要作用。本研究首次比较了在小鼠中侧内嗅皮层和前梨状皮层气味诱发的单个单位和局部场电位活动。在给予一系列三种纯气味和三种重叠气味混合物的氨基甲酸乙酯麻醉小鼠中进行了记录。结果表明，与梨状皮层相比，侧内嗅皮层自发和气味诱发的单位活动较低。此外，与梨状皮层相比，侧内嗅皮层的单位对更有限的一组气味有反应。相反，在 theta 波段，侧内嗅皮层的局部场电位活动的气味诱发功率变化大于梨状皮层。侧内嗅皮层中高度气味特异性和受限的放电表明，它可能在调节气味特异性、经验和状态依赖性嗅觉编码中发挥作用。
