Doheny Eye Institute, Los Angeles, California 90033, USA.
Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6526-31. doi: 10.1167/iovs.12-9909.
To assess the prevalence of peripheral fundus autofluorescence (FAF) abnormalities in a variety of diseases seen at a tertiary retina clinic.
We conducted a retrospective review of cases seen at the Doheny Eye Institute between November 2009 and May 2011, who had ultra-widefield FAF and pseudocolor imaging performed on new models of scanning laser ophthalmoscopes. Patients with a history of previous therapies that could alter the FAF findings, including vitrectomy, cryotherapy, laser photocoagulation, or photodynamic therapy, were excluded from the analysis. Based on their primary diagnosis the eyes were grouped into nine disease categories: age-related macular degeneration, central serous retinopathy, dystrophy, inflammatory disorders, ocular tumor, retinal vascular disorders, other, normal, and unknown. All FAF and accompanying pseudocolor images were reviewed independently by two reading center-certified graders.
A total of 470 eyes of 248 patients were included for analysis of which 461 eyes had images of sufficient quality for grading. The prevalence of peripheral findings was 65.5% (n = 302) for FAF images and 68.5% (n = 316) for the pseudocolor images (P < 0.001). The prevalence of peripheral abnormalities differed significantly between the disease categories ranging from 18.5% to 82.2% for FAF and 18.5% to 82.4% for pseudocolor images.
Peripheral FAF abnormalities are frequent and readily revealed by FAF imaging. Interestingly, even cases with presumably macular disease demonstrated a high prevalence of peripheral findings. Further investigation in prospective studies is warranted.
评估在一家三级视网膜诊所中看到的各种疾病中外周眼底自发荧光（FAF）异常的发生率。
我们对 2009 年 11 月至 2011 年 5 月期间在 Doheny 眼科研究所就诊的病例进行了回顾性研究，这些患者在新型扫描激光检眼镜上进行了超广角 FAF 和假彩色成像。排除了有先前可能改变 FAF 发现的治疗史（包括玻璃体切除术、冷冻疗法、激光光凝或光动力疗法）的患者。根据其主要诊断，将这些眼分为九种疾病类别：年龄相关性黄斑变性、中心性浆液性视网膜病变、营养不良、炎症性疾病、眼部肿瘤、视网膜血管疾病、其他、正常和未知。两名阅读中心认证的分级员独立对所有 FAF 和伴随的假彩色图像进行了评估。
共有 248 例患者的 470 只眼被纳入分析，其中 461 只眼的图像质量足以进行分级。FAF 图像的外周发现率为 65.5%（n=302），假彩色图像的外周发现率为 68.5%（n=316）（P<0.001）。不同疾病类别的外周异常发生率差异显著，FAF 为 18.5%至 82.2%，假彩色图像为 18.5%至 82.4%。
外周 FAF 异常很常见，FAF 成像可轻易发现。有趣的是，即使是那些假定有黄斑疾病的病例，也表现出高发生率的外周发现。需要在前瞻性研究中进一步调查。
