Suetsugu Tetsuyuki, Kato Aki, Yoshida Munenori, Yasukawa Tsutomu, Nishiwaki Akiko, Hasegawa Norio, Usui Hideaki, Ogura Yuichiro
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences; Department of Ophthalmology, General Kamiiida Daiichi Hospital.
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences.
Clin Ophthalmol. 2016 Dec 14;10:2497-2503. doi: 10.2147/OPTH.S120402. eCollection 2016.
We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument.
A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments.
Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (<0.001, =0.03, and <0.001, respectively) than control eyes (18.8%). There were no significant differences (=0.76) between the frequencies in untreated and treated eyes.
Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes.
我们旨在使用广角成像仪器评估湿性年龄相关性黄斑变性（AMD）患者外周眼底自发荧光（FAF）异常的患病率。
进行了一项回顾性病例对照研究，纳入46例日本湿性AMD患者的66只眼和20例对照患者的32只眼。获取了典型AMD（28例患者的37只眼）、息肉样脉络膜血管病变（PCV，20例患者的22只眼）和视网膜血管瘤样增殖（RAP，4例患者的7只眼）的广角FAF图像。两名经验丰富的眼科医生独立对图像的斑点状、颗粒状和钱币状模式进行分级。主要观察指标为疾病亚组和治疗方式的外周FAF异常频率及相对风险。
湿性AMD眼中51.5%发现外周FAF模式异常，而对照眼中这一比例为18.8%（<0.001）。湿性AMD眼中斑点状、颗粒状和钱币状模式分别占45.5%、31.8%和16.7%。各疾病亚组（典型AMD为54.1%；PCV为36.4%；RAP为85.7%）外周FAF异常频率均显著高于对照眼（18.8%）（分别为<0.001、=0.03和<0.001）。未治疗眼和治疗眼的异常频率之间无显著差异（=0.76）。
与对照眼相比，日本湿性AMD患者的眼睛外周FAF异常患病率更高。在三种疾病亚型中，PCV眼中异常模式的患病率最低。
