Unité d'Immunologie, Hématologie et Rhumatologie Pédiatriques, AP-HP, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.
J Infect Dis. 2012 Oct;206(8):1269-74. doi: 10.1093/infdis/jis498. Epub 2012 Aug 7.
We report the first prospective study describing the prevalence and clinical consequences of norovirus infection in hospitalized children with primary immunodeficiencies. Fecal samples from 62 children were systematically screened for virus. Norovirus was the most frequent pathogen (11 of 24 positive samples) found in both combined and humoral immunocompromised children. Norovirus shedding was associated with gastrointestinal symptoms and concomitant viremia in 54.5% and 25% of cases, respectively. Norovirus excretion was prolonged: 57.1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies.
我们报告了首例前瞻性研究，描述了在原发性免疫缺陷住院儿童中诺如病毒感染的流行情况和临床后果。对 62 名儿童的粪便样本进行了系统筛查，以检测病毒。诺如病毒是在联合免疫和体液免疫缺陷儿童中均发现的最常见病原体（24 个阳性样本中的 11 个）。分别有 54.5%和 25%的病例出现胃肠道症状和病毒血症。诺如病毒的排泄时间较长：中位随访 9.5 个月后，仍有 57.1%的粪便样本呈阳性。需要进一步开展大型纵向研究，以评估原发性免疫缺陷患者诺如病毒排出的临床后果。
