胰腺神经内分泌肿瘤的当前管理

The current management of pancreatic neuroendocrine tumors.

作者信息

Ellison Trevor A, Edil Barish H

机构信息

Department of Surgery, The Johns Hopkins Hospital, 1550 Orleans Street, CRB II, Room 506, Baltimore, MD 21287, USA.

出版信息

Adv Surg. 2012;46:283-96. doi: 10.1016/j.yasu.2012.04.002.

DOI:10.1016/j.yasu.2012.04.002

PMID:22873046

Abstract

PanNETs constitute a rare and heterogeneous group of pancreatic neoplasms whose overall prognosis is better than the more common pancreatic adenocarcinoma. Although surgery is the only treatment that provides a cure, many adjuvant therapies have been explored with some new, exciting, targeted therapies just approved for PanNETs. With growing interest in this type of neoplasm, an increasing number of clinical trials and natural history studies should shed light on the best management for these patients.

摘要

胰腺神经内分泌肿瘤（PanNETs）是一组罕见且异质性的胰腺肿瘤，其总体预后优于更常见的胰腺腺癌。尽管手术是唯一能治愈的治疗方法，但人们已经探索了许多辅助治疗方法，并且一些针对PanNETs的新型、令人兴奋的靶向治疗刚刚获批。随着对这类肿瘤的兴趣日益浓厚，越来越多的临床试验和自然史研究应该会为这些患者的最佳管理提供线索。