Zhukovs'ka A S, Shysh A M, Moĭbenko O O
Fiziol Zh (1994). 2012;58(2):16-26.
We studied the influence of omega-3 polyunsaturated fatty acids (PUFAs) on respiration, swelling of rat heart mitochondria and changes in rat heart fatty acid composition in tissue homogenate in rats with streptozotocin induced diabetes mellitus (diabetes), which was induced by single intraperitoneal administration of 55 mg/kg streptozotocin. We found that application of these acids increased parameters of active mitochondrial respiration V3 at 63.7%, controlled breathing V4 at 30.7% and the rate of phosphorylation by 18.9% in animals with experimental diabetes. We proved their ability to reduce swelling of mitochondria in heart at streptozotocin induced diabetes. In addition, we established changes of fatty acid composition of cell membranes in hearts under diabetic conditions with omega-3 PUFAs influence. The obtained results allow to conclude that the omega-3 PUFA have a positive effect on functional parameters of mitochondria due to stabilization cell membranes of rat heart with diabetes.
我们研究了ω-3多不饱和脂肪酸（PUFAs）对链脲佐菌素诱导的糖尿病大鼠（糖尿病）心脏线粒体呼吸、肿胀以及组织匀浆中大鼠心脏脂肪酸组成变化的影响，该糖尿病是通过单次腹腔注射55mg/kg链脲佐菌素诱导产生的。我们发现，在实验性糖尿病动物中，应用这些酸可使线粒体活性呼吸参数V3增加63.7%，控制呼吸参数V4增加30.7%，磷酸化速率增加18.9%。我们证明了它们在链脲佐菌素诱导的糖尿病中具有减轻心脏线粒体肿胀的能力。此外，我们还确定了在ω-3多不饱和脂肪酸影响下糖尿病状态下心脏细胞膜脂肪酸组成的变化。所得结果表明，ω-3多不饱和脂肪酸对糖尿病大鼠心脏线粒体功能参数具有积极影响，这是由于其稳定了大鼠心脏的细胞膜。
