Panasiuk O S, Shysh A M, Moĭbenko O O
Fiziol Zh (1994). 2014;60(1):18-24.
We have studied the functional parameters of mitochondria from hearts after isopreterenol-induced injury (two subcutaneous injections of isopreterenol at the dose 60 mg/kg/day). We investigated the influence of dietary omega-3 polyunsaturated fatty acids (omega-3 PUFAs) administered to rats (Epadol, 0.1 mg/100 gr of weight for 4 weeks) on these parameters. Isoproterenol-induced heart injury leads to a decreased parameters of respiration of isolated mitochondria in the presence of succinate. Administration of omega-3 PUFAs significantly restored the respiration rate of mitochondria: the state 3 respiration was increased by 70.12%, the state 4 by 39.87% and the respiratory control ratio by 45.19% compared to the corresponding parameters of experimental group. Also, it was shown the ability of omega-3 PUFAs to decrease mitochondria swelling (by 60%) in nominally free calcium solution. The results of the study indicate that omega-3 PUFAs improve the altered functions of the heart mitochondria evoked by isoproterenol-induced injury.
我们研究了异丙肾上腺素诱导损伤后（以60mg/kg/天的剂量皮下注射两次异丙肾上腺素）心脏线粒体的功能参数。我们调查了给予大鼠膳食ω-3多不饱和脂肪酸（ω-3 PUFAs）（Epadol，0.1mg/100g体重，持续4周）对这些参数的影响。异丙肾上腺素诱导的心脏损伤导致在琥珀酸存在下分离线粒体的呼吸参数降低。与实验组的相应参数相比，给予ω-3 PUFAs显著恢复了线粒体的呼吸速率：状态3呼吸增加了70.12%，状态4呼吸增加了39.87%，呼吸控制率增加了45.19%。此外，研究还表明ω-3 PUFAs能够在名义上无钙的溶液中减少线粒体肿胀（减少60%）。研究结果表明，ω-3 PUFAs改善了异丙肾上腺素诱导损伤引起的心脏线粒体功能改变。
