• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

压力、炎症与衰老。

Stress, inflammation, and aging.

出版信息

Am J Geriatr Psychiatry. 2012 Sep;20(9):729-33. doi: 10.1097/JGP.0b013e31826573cf.

DOI:10.1097/JGP.0b013e31826573cf
PMID:22874577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3428505/
Abstract

This editorial provides a summary of the state of research on stress-related changes associated with aging and discuss how factors such as inflammation and sex steroid alterations may interact with psychosocial stress to affect the risk for mood and cognitive disturbance in older individuals. The authors provide an integrated summary of four studies reported in this issue of the journal and views on future direction in stress and aging research and interventions targeting resilience to stress.

摘要

这篇社论概述了与衰老相关的应激变化的研究现状,并讨论了炎症和性激素改变等因素如何与心理社会应激相互作用,影响老年人情绪和认知障碍的风险。作者综合总结了本期杂志中报告的四项研究,并就应激和衰老研究以及针对应激适应力的干预措施的未来方向提出了看法。

相似文献

1
Stress, inflammation, and aging.压力、炎症与衰老。
Am J Geriatr Psychiatry. 2012 Sep;20(9):729-33. doi: 10.1097/JGP.0b013e31826573cf.
2
The fragile mind: early life stress and inflammatory disease.脆弱的心灵:早年生活压力与炎症性疾病
Endocrinology. 2008 Jun;149(6):2724-6. doi: 10.1210/en.2008-0320.
3
Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved?疼痛、抑郁与炎症:是否存在相互关联的致病因素?
Mod Trends Pharmacopsychiatry. 2015;30:22-35. doi: 10.1159/000435930. Epub 2015 Sep 18.
4
Glucocorticoids and inflammation: a double-headed sword in depression? How do neuroendocrine and inflammatory pathways interact during stress to contribute to the pathogenesis of depression?糖皮质激素与炎症:抑郁症中的双刃剑?在应激过程中,神经内分泌和炎症途径如何相互作用从而导致抑郁症的发病机制?
Mod Trends Pharmacopsychiatry. 2013;28:127-43. doi: 10.1159/000343980. Epub 2013 Feb 27.
5
Combat loneliness to slow the aging process. Feeling isolated could accelerate aging, affecting inflammation and infection at the cellular level.对抗孤独以减缓衰老过程。感到孤独可能会加速衰老,在细胞层面影响炎症和感染。
Duke Med Health News. 2007 Dec;13(12):6-7.
6
Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability.将与年龄相关的生物衰退与衰弱及晚年脆弱性联系起来。
Nestle Nutr Inst Workshop Ser. 2015;83:1-10. doi: 10.1159/000382052. Epub 2015 Oct 20.
7
Links Between Stress, Sleep, and Inflammation: Are there Sex Differences?压力、睡眠与炎症之间的关联:性别差异是否存在?
Curr Psychiatry Rep. 2019 Feb 7;21(2):8. doi: 10.1007/s11920-019-0993-4.
8
Chronic behavioral stress exaggerates motor deficit and neuroinflammation in the MPTP mouse model of Parkinson's disease.慢性行为应激会加剧帕金森病MPTP小鼠模型中的运动功能障碍和神经炎症。
Transl Psychiatry. 2016 Feb 9;6(2):e733. doi: 10.1038/tp.2016.1.
9
Lost Touch? Implications of Physical Touch for Physical Health.失去联系?身体接触对身体健康的影响。
J Gerontol B Psychol Sci Soc Sci. 2021 Feb 17;76(3):e111-e115. doi: 10.1093/geronb/gbaa134.
10
Increase in systemic vascular resistance during acute mental stress in patients with rheumatoid arthritis with high-grade systemic inflammation.类风湿关节炎伴高度全身炎症患者在急性精神应激期间全身血管阻力增加。
Biol Psychol. 2008 Jan;77(1):106-10. doi: 10.1016/j.biopsycho.2007.09.002. Epub 2007 Sep 11.

引用本文的文献

1
Psychosocial stressors and cognitive function: An analysis using data from the English longitudinal study of ageing.心理社会压力源与认知功能:一项基于英国老年纵向研究数据的分析
J Prev Alzheimers Dis. 2025 Sep;12(8):100232. doi: 10.1016/j.tjpad.2025.100232. Epub 2025 Jun 17.
2
Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain.雌二醇通过雌激素受体β信号通路介导雄性大脑中的应激易感性。
Mol Psychiatry. 2025 Apr 24. doi: 10.1038/s41380-025-03027-8.
3
Allostatic load score and lifestyle factors in the SWAN cohort: A longitudinal analysis.SWAN队列中的应激负荷评分与生活方式因素:一项纵向分析。
Public Health Pract (Oxf). 2025 Feb 12;9:100590. doi: 10.1016/j.puhip.2025.100590. eCollection 2025 Jun.
4
Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.针对主观认知能力下降个体的数字干预对抑郁和白细胞介素-18影响的脑连接相关性。
Sci Rep. 2025 Feb 26;15(1):6863. doi: 10.1038/s41598-025-91457-3.
5
Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment.精神疾病动物模型中的线粒体移植:一种精神疾病治疗的新方法。
Biomolecules. 2025 Jan 27;15(2):184. doi: 10.3390/biom15020184.
6
The Role of Cortisol and Dehydroepiandrosterone in Obesity, Pain, and Aging.皮质醇和脱氢表雄酮在肥胖、疼痛及衰老中的作用
Diseases. 2025 Feb 1;13(2):42. doi: 10.3390/diseases13020042.
7
Multimorbidity and Depressive Symptoms and their Association with Self-Reported Health and Life Satisfaction Among Adults Aged ≥ 50 Years in Mexico.墨西哥50岁及以上成年人的多重疾病、抑郁症状及其与自我报告的健康状况和生活满意度的关联
J Cross Cult Gerontol. 2025 Mar;40(1):107-121. doi: 10.1007/s10823-025-09521-4. Epub 2025 Jan 23.
8
"Rest of the folks are tired and weary": The impact of historical lynchings on biological and cognitive health for older adults racialized as Black.“其他人疲惫不堪”:历史上的私刑对被种族化为黑人的老年人的生物和认知健康的影响。
Soc Sci Med. 2025 Jan;364:117537. doi: 10.1016/j.socscimed.2024.117537. Epub 2024 Nov 22.
9
Whole-Body Cryotherapy Reduces Systemic Inflammation in Healthy Adults: Pilot Cohort Study.全身冷冻疗法可减轻健康成年人的全身炎症:初步队列研究。
Interact J Med Res. 2024 Nov 22;13:e60942. doi: 10.2196/60942.
10
Effects of Yogic Practices Synchronized With Bandha and Kumbhaka on Biological and Psychological Factors of Aging in COVID-19-Recovered Patients: A Randomized Controlled Trial.与收束法和屏息法同步的瑜伽练习对新冠康复患者衰老的生物学和心理因素的影响:一项随机对照试验
Cureus. 2024 Oct 19;16(10):e71884. doi: 10.7759/cureus.71884. eCollection 2024 Oct.

本文引用的文献

1
Personal Risk and Resilience Factors in the Context of Daily Stress.日常压力情境下的个人风险与复原力因素
Annu Rev Gerontol Geriatr. 2012 Jan 1;32(1):251-274. doi: 10.1891/0198-8794.32.251. Epub 2012 Feb 1.
2
Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults.白细胞介素-6 与健康和抑郁老年人的编码和回忆记忆功能。
Am J Geriatr Psychiatry. 2012 Sep;20(9):753-63. doi: 10.1097/JGP.0b013e31825d08d6.
3
The effects of age and estrogen on stress responsivity in older women.年龄和雌激素对老年女性应激反应的影响。
Am J Geriatr Psychiatry. 2012 Sep;20(9):734-43. doi: 10.1097/JGP.0b013e31825c0a14.
4
Sleep disturbance and older adults' inflammatory responses to acute stress.睡眠障碍与老年人对应激的炎症反应。
Am J Geriatr Psychiatry. 2012 Sep;20(9):744-52. doi: 10.1097/JGP.0b013e31824361de.
5
Mitigating cellular inflammation in older adults: a randomized controlled trial of Tai Chi Chih.缓解老年人细胞炎症:太极气功的随机对照试验。
Am J Geriatr Psychiatry. 2012 Sep;20(9):764-72. doi: 10.1097/JGP.0b013e3182330fd3.
6
Cognitive response to estradiol in postmenopausal women is modified by high cortisol.绝经后妇女的雌二醇认知反应受高皮质醇影响。
Neurobiol Aging. 2012 Apr;33(4):829.e9-20. doi: 10.1016/j.neurobiolaging.2011.07.002. Epub 2011 Aug 19.
7
Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women.雌激素治疗会损害绝经后妇女在心理社会应激和单胺耗竭后的认知表现。
Menopause. 2010 Jul;17(4):860-73. doi: 10.1097/gme.0b013e3181e15df4.
8
Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study.瑞典女性唾液皮质醇水平随年龄和性别而异,且与腰臀比呈负相关:一项横断面研究。
BMC Endocr Disord. 2009 Jun 21;9:16. doi: 10.1186/1472-6823-9-16.
9
Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women.在绝经后女性中,雌激素给药会在单胺能耗竭和心理社会应激后对情绪产生负面影响。
Neuropsychopharmacology. 2008 Jun;33(7):1514-27. doi: 10.1038/sj.npp.1301530. Epub 2007 Aug 15.
10
Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol.老年人血清素转运体基因多态性、记忆力与海马体积:与皮质醇的关联及相互作用
Mol Psychiatry. 2007 Jun;12(6):544-55. doi: 10.1038/sj.mp.4001978. Epub 2007 Mar 13.