Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, Los Angeles, CA 90095, USA.
Am J Geriatr Psychiatry. 2012 Sep;20(9):764-72. doi: 10.1097/JGP.0b013e3182330fd3.
To evaluate the effects of a behavioral intervention, Tai Chi Chih (TCC) on circulating markers of inflammation in older adults.
A prospective, randomized, controlled trial with allocation to two arms, TCC and health education (HE), 16 weeks of intervention administration, and 9 weeks follow-up.
A total of 83 healthy older adults, aged 59 to 86 years.
The primary endpoint was circulating levels of interleukin 6 (IL-6). Secondary outcomes were circulating levels of C-reactive protein, soluble IL-1 receptor antagonist, soluble IL-6 receptor, soluble intercellular adhesion molecule, and IL-18. Severity of depressive symptoms, sleep quality, and physical activity was also assessed over the treatment trial.
Among those older adults with high levels of IL-6 at entry, a trend for a treatment group by time interaction was found (F[1,70] = 3.48, p = 0.07), in which TCC produced a drop of IL-6 levels comparable to those found in TCC and HE subgroups who had low levels of IL-6 at entry (t72's = 0.80, 1.63, p's >0.10), whereas IL-6 in HE remained higher than the TCC and HE subgroups with low entry IL-6 (t72 = 2.47, p = 0.02; t72 = 1.71, p = 0.09). Decreases in depressive symptoms in the two treatment groups correlated with decreases of IL-6 (r = 0.28, p <0.05). None of the other cellular markers of inflammation changed in TCC versus HE.
TCC can be considered a useful behavioral intervention to reduce circulating levels of IL-6 in older adults who show elevated levels of this inflammatory marker and are at risk for inflammation-related morbidity.
评估行为干预——太极气功（TCC）对老年人群循环炎症标志物的影响。
一项前瞻性、随机、对照试验，分为 TCC 组和健康教育（HE）组两个组别，干预时长 16 周，随访 9 周。
共 83 名健康的老年人，年龄 59 至 86 岁。
主要终点是白细胞介素 6（IL-6）的循环水平。次要结果包括 C 反应蛋白、可溶性白细胞介素 1 受体拮抗剂、可溶性白细胞介素 6 受体、可溶性细胞间黏附分子和白细胞介素 18 的循环水平。在治疗试验过程中还评估了抑郁症状严重程度、睡眠质量和身体活动。
在那些进入研究时具有高水平 IL-6 的老年人中，发现治疗组与时间的交互作用存在趋势（F[1,70] = 3.48，p = 0.07），TCC 可降低 IL-6 水平，与那些进入研究时 IL-6 水平较低的 TCC 和 HE 亚组相当（t72's = 0.80，1.63，p's >0.10），而 HE 中的 IL-6 仍高于 TCC 和 HE 亚组的低初始 IL-6（t72 = 2.47，p = 0.02；t72 = 1.71，p = 0.09）。两个治疗组的抑郁症状减轻与 IL-6 的减少相关（r = 0.28，p <0.05）。TCC 与 HE 相比，其他炎症细胞标志物均无变化。
TCC 可被视为一种有用的行为干预措施，可降低具有升高的炎症标志物水平且有炎症相关发病风险的老年人群的循环 IL-6 水平。
