Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Diabetes Care. 2013 Jan;36(1):111-7. doi: 10.2337/dc12-0421. Epub 2012 Aug 8.
We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age.
We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.
β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.
β-Cell mass in human obesity increases by ~50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.
我们旨在确定肥胖和高龄对人体胰岛β细胞质量、β细胞凋亡和β细胞复制的影响。
我们检测了 167 名非糖尿病个体的人尸胰腺，年龄在 20-102 岁之间。在 53 名正常体重者和 61 名肥胖者中，我们研究了肥胖对β细胞质量的影响，并在 106 名正常体重者中研究了衰老的影响。
肥胖者的β细胞质量增加了约 50%（从 0.8 克增加到 1.2 克）。随着年龄的增长，外分泌胰腺会发生萎缩，但β细胞质量却显著保留下来。在整个生命过程中，瘦人β细胞的复制或凋亡很少，肥胖或衰老也不会导致其发生可检测的变化。
肥胖患者的β细胞质量增加了约 50%，这是由于β细胞数量增加所致，但其来源尚不清楚。β细胞质量在高龄人群中得到了很好的保存。
