Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China.
J Tradit Chin Med. 2012 Jun;32(2):199-202. doi: 10.1016/s0254-6272(13)60011-4.
To test the influence of acupuncture on cognitive function and a marker of oxidative DNA damage in patients with vascular dementia (VD).
Sixteen VD patients were evaluated before and after acupuncture, using the Folstein mini-mental state examination-revised (MMSE-R) to assess cognitive function, and the ADL-R scale to assess independence in activities of daily living (ADL). Life quality was evaluated using the DEMQOL (Dementia quality of life questionnaire) questionnaire, and syndromes and expression of vascular dementia were evaluated with the Scale for the differentiation of syndromes of vascular dementia (SDSVD). In addition, the urine concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG)--a marker of oxidative damage--was quantified with enzyme-linked immunosorbent assay.
The MMSE-R and DEMQOL scores were higher after acupuncture than before (P < 0.05), while there were no obvious differences in the ADL-R or SDSVD scores (P > 0.05). The 8-OHdG content in urine significantly decreased after acupuncture (P < 0.05).
Acupuncture reduces the levels of 8-OHdG and improves cognitive function and quality of life in VD patients, suggesting that acupuncture is beneficial at least in part by preventing oxidative damage.
观察针刺对血管性痴呆（VD）患者认知功能及氧化应激标志物 8-羟基脱氧鸟苷（8-OHdG）的影响。
将 16 例 VD 患者针刺前后分别进行简易精神状态检查量表修订版（MMSE-R）、日常生活能力量表（ADL-R）、痴呆患者生活质量量表（DEMQOL）及血管性痴呆证候量表（SDSVD）评分，采用酶联免疫吸附法检测尿 8-OHdG 浓度。
针刺后患者 MMSE-R 及 DEMQOL 评分均高于针刺前（P＜0.05），ADL-R 及 SDSVD 评分与针刺前比较差异无统计学意义（P＞0.05）；针刺后患者尿 8-OHdG 浓度明显降低（P＜0.05）。
针刺可降低 VD 患者尿 8-OHdG 水平，改善认知功能及生活质量，提示针刺可能通过抗氧化应激损伤发挥作用。
