Mann J J, Manevitz A Z, Chen J S, Johnson K S, Adelsheimer E F, Azima-Heller R, Massina A, Wilner P J
Laboratory of Neuropharmacology, University of Pittsburgh, PA 15213.
Psychiatry Res. 1990 Nov;34(2):127-37. doi: 10.1016/0165-1781(90)90014-v.
The role of activation of adrenergic neurons by electroconvulsive therapy (ECT) in its antidepressant action was studied by examining acute sympathetic nervous system (SNS) responses to ECT during a course of treatment in patients with melancholia. ECT had an acute dose-dependent effect on plasma norepinephrine (NE) level and blood pressure. The postictal increase in plasma NE and blood pressure was independent of electrical seizure duration. Acute levels of NE and epinephrine after ECT correlated positively with ECT dosage. No cumulative effect of repeated ECT was found on the SNS responses. ECT does activate the SNS in a dose-dependent fashion. However, alternative strategies seem necessary for studying the action of ECT on noradrenergic neurons to identify effects that are cumulative, correspond more closely to the time course of its antidepressant action, and correlate with clinical outcome.
通过检查忧郁症患者在一个疗程治疗期间对电休克疗法（ECT）的急性交感神经系统（SNS）反应，研究了ECT激活肾上腺素能神经元在其抗抑郁作用中的角色。ECT对血浆去甲肾上腺素（NE）水平和血压有急性剂量依赖性效应。发作后血浆NE和血压的升高与癫痫发作持续时间无关。ECT后NE和肾上腺素的急性水平与ECT剂量呈正相关。未发现重复ECT对SNS反应有累积效应。ECT确实以剂量依赖性方式激活SNS。然而，似乎需要采用其他策略来研究ECT对去甲肾上腺素能神经元的作用，以确定具有累积性、更符合其抗抑郁作用时间进程且与临床结果相关的效应。
