Babu Banarasi Das Northern India Institute of Technology, BBD City, Faizabad Road, Lucknow, U.P., India.
Mini Rev Med Chem. 2013 Apr;13(4):565-83. doi: 10.2174/1389557511313040009.
The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.
哌啶-4-酮已被报道为多功能中间体。它们已通过多种方法合成，包括曼尼希反应和立体选择性合成。哌啶-4-酮已被报道具有多种药理活性，包括抗癌和抗 HIV 活性。药效团可以进行适当修饰，以实现更好的受体相互作用和生物活性。对核的重新关注重新确立了哌啶-4-酮在药物化学中的重要性。本文综述了过去十年中哌啶-4-酮在合成方案、结构表征、立体化学和重要生物学活性方面的最新研究趋势。
