Kołodziej T, Maj J, Ziarkiewicz M
Kliniki Dermatologicznej AM we Wrocławiu.
Przegl Dermatol. 1990 Nov-Dec;77(6):413-6.
A typical case of Werner's syndrome was described. All characteristic features were present i.e.: atrophy of muscle and subcutaneous tissue, especially in distal parts of limbs, reduced and gray hairs, numerous atrophic ulcers and hyperkeratotic lesions in points under the pressure (elbow, feet), diffused osteoporosis in all bones, the most intensive in hands and feet, activity dental caries, bilateral cataract, high pitched, horse voice, caused by atrophy of voice cords, endocrinologic disturbances especially concerning testosterone, follicle stimulating hormone, and prolactin, hypoplasia of external genitals, the abnormal blood glucose curve. Far reaching resemblance of the Werner's syndrome to the physiological senility was emphasized. Good reaction to anabolic drugs was described.
描述了一例典型的沃纳综合征病例。所有特征均存在，即：肌肉和皮下组织萎缩，尤其是四肢远端；头发减少且变白；受压部位（肘部、足部）有许多萎缩性溃疡和角化过度病变；全身骨骼弥漫性骨质疏松，以手足部最为明显；活动性龋齿；双侧白内障；因声带萎缩导致声音高亢、嘶哑；内分泌紊乱，尤其是睾酮、促卵泡激素和催乳素方面；外生殖器发育不全；血糖曲线异常。强调了沃纳综合征与生理性衰老极为相似。还描述了对同化药物的良好反应。
