Boston and Cambridge, Mass. From the Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, and the Departments of Biological Engineering and Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology.
Plast Reconstr Surg. 2012 Dec;130(6):879e-887e. doi: 10.1097/PRS.0b013e31826da023.
Nanotechnology has made inroads over time within surgery and medicine. Translational medical devices and therapies based on nanotechnology are being developed and put into practice. In plastic surgery, it is anticipated that this new technology may be instrumental in the future. Microelectromechanical systems are one form of nanotechnology that offers the ability to develop miniaturized implants for use in the treatment of numerous clinical conditions. The authors summarize their published preliminary findings regarding a microelectromechanical systems-based electrochemical stimulation method through modulation of ions around the nerve that is potentially implantable and clinically efficacious, and expand upon current and potential usages of nanotechnology in plastic surgery.
Sciatic nerves (n = 100) of 50 American bullfrogs were placed on a microfabricated planar gold electrode array and stimulated electrically. Using Ca(2+)-selective membranes, ion concentrations were modulated around the nerve environment in situ. In addition, a comprehensive review of the literature was performed to identify all available data pertaining to the use of nanotechnology in medicine.
A 40 percent reduction of the electrical threshold value was observed using the Ca(2+) ion-selective membrane. The uses of nanotechnology specifically applicable to plastic surgery are detailed.
Nanotechnology may likely lead to advancements in the art and science of plastic surgery. Using microelectromechanical systems nanotechnology, the authors have demonstrated a novel means of modulating the activation of nerve impulses. These findings have potentially significant implications for the design of special nano-enhanced materials that can be used to promote healing, control infection, restore function, and aid nerve regeneration and rehabilitation.
纳米技术在外科和医学领域已经取得了进展。基于纳米技术的转化医学设备和疗法正在开发和应用。在整形外科学中，预计这项新技术将在未来发挥重要作用。微机电系统是纳米技术的一种形式，它提供了开发用于治疗许多临床病症的微型植入物的能力。作者总结了他们发表的关于基于微机电系统的电化学刺激方法的初步发现，该方法通过调节神经周围的离子，具有潜在的可植入性和临床疗效，并扩展了纳米技术在整形外科学中的当前和潜在用途。
将 50 只美洲牛蛙的坐骨神经（n = 100）放置在微制造的平面金电极阵列上，并进行电刺激。使用 Ca(2+) 选择性膜，原位调节神经周围的离子浓度。此外，还进行了全面的文献综述，以确定与纳米技术在医学中的应用相关的所有可用数据。
使用 Ca(2+) 离子选择性膜观察到电阈值降低了 40%。详细介绍了具体适用于整形外科学的纳米技术用途。
纳米技术可能会推动整形外科学的艺术和科学的进步。作者使用微机电系统纳米技术，展示了一种调节神经冲动激活的新方法。这些发现对于设计特殊的纳米增强材料具有潜在的重要意义，这些材料可用于促进愈合、控制感染、恢复功能以及帮助神经再生和康复。
