Solidum Jea Giezl N, Ceriales Jeremy A, Ong Erika P, Ornos Eric David B, Relador Ruth Joy L, Quebral Elgin Paul B, Lapeña Jose Florencio F, Tantengco Ourlad Alzeus G, Lee Ka Yiu
MD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Maxillofac Plast Reconstr Surg. 2023 Mar 30;45(1):15. doi: 10.1186/s40902-023-00383-9.
Nanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues.
In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression.
Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS.
纳米技术和纳米医学是整形与重建外科（PRS）中新兴的领域。纳米材料的使用常常与再生医学相伴。由于其纳米尺度，这些材料能在细胞和分子水平刺激修复。纳米材料可作为纳米复合聚合物的组分，从而通过改善支架特性、细胞黏附及组织再生来增强整体的生化和生物力学性能。例如，它们也可被制成基于纳米颗粒的递送系统，用于信号因子或抗菌剂的控释。然而，在该领域仍需对基于纳米颗粒的递送系统开展更多研究。纳米材料还被用作神经、肌腱及其他软组织的支架。
在本综述中，我们聚焦于基于纳米颗粒的递送系统以及在PRS中靶向细胞以实现反应和再生的纳米颗粒。具体而言，我们研究它们在各种组织再生、皮肤及伤口愈合以及感染控制中的作用。具有固有生物学特性的细胞表面靶向、控释及无机纳米颗粒制剂能够促进伤口愈合、肿瘤可视化/成像、组织活力，并通过免疫抑制减少感染以及移植物/移植排斥反应。
纳米医学如今也正与电子学、治疗诊断学及先进生物工程技术相结合。总体而言，它是一个有前景的领域，能够改善PRS患者的临床结局。
