Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Chin Med J (Engl). 2012 Jun;125(11):1975-9.
Curcumin, an active ingredient of turmeric with antioxidant and anti-inflammatory properties has recently been reported to have anticonvulsant effects in several animal models of epilepsy. This study aimed to investigate the effects of curcumin on the pilocarpine rat model of status epilepticus.
The effect of intraperitoneal administration of curcumin (30, 100, and 300 mg/kg) on pilocarpine-induced seizures in rats was tested. The correlation between seizure activity and hippocampal levels of nitric oxide synthase and free radicals was quantified. Whether curcumin treatment modulated these parameters was also investigated.
Curcumin significantly increased seizure threshold at doses of 100 and 300 mg/kg. Rats with pilocarpine- induced seizures showed significantly elevated levels of malonaldehyde, nitric oxide synthase, and lactate dehydrogenase, but decreased levels of superoxide dismutase and glutathione compared with normal control rats. At doses of 100 and 300 mg/kg, curcumin reversed the effects of pilocarpine-induced seizures on nitric oxide synthase, lactate dehydrogenase, glutathione, and superoxide dismutase. However, curcumin did not restore the elevated malonaldehyde levels.
Curcumin has anticonvulsant activity in the pilocarpine rat model of seizures, and that modulation of free radicals and nitric oxide synthase may be involved in this effect.
姜黄素是姜黄的一种活性成分，具有抗氧化和抗炎特性，最近有报道称其在几种癫痫动物模型中具有抗惊厥作用。本研究旨在研究姜黄素对匹罗卡品大鼠癫痫持续状态模型的影响。
检测腹腔给予姜黄素（30、100 和 300mg/kg）对大鼠匹罗卡品诱导的癫痫发作的影响。量化了癫痫发作活动与海马中一氧化氮合酶和自由基之间的相关性。还研究了姜黄素治疗是否调节了这些参数。
姜黄素在 100 和 300mg/kg 剂量下显著提高了惊厥发作的阈值。与正常对照大鼠相比，匹罗卡品诱导的癫痫发作大鼠的丙二醛、一氧化氮合酶和乳酸脱氢酶水平显著升高，而超氧化物歧化酶和谷胱甘肽水平降低。在 100 和 300mg/kg 剂量下，姜黄素逆转了匹罗卡品诱导的癫痫发作对一氧化氮合酶、乳酸脱氢酶、谷胱甘肽和超氧化物歧化酶的影响。然而，姜黄素并没有恢复升高的丙二醛水平。
姜黄素在匹罗卡品诱导的大鼠癫痫发作模型中具有抗惊厥活性，自由基和一氧化氮合酶的调节可能参与了这种作用。
