Department of Obstetrics and Gynecology, Medical University of Vienna General Hospital, Vienna, Austria.
Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):33-6. doi: 10.1016/j.ejogrb.2012.07.013. Epub 2012 Aug 11.
To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth.
In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth.
A significant association was found between the presence of the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6 [0.3-1.0]). No significant association was found between the IL1B -511C>T polymorphism and preterm birth (p=0.471, OR 1.3 [0.7-2.3]).
Our findings suggest that the IL1B +3953C>T polymorphism is associated with a risk reduction for preterm birth in Caucasian women, possibly by altering the inflammatory response during pregnancy.
探讨白细胞介素-1β（IL1B）基因中的两种遗传变异与早产之间的关联。
在这项病例对照研究中，我们检测了其两个常见多态性（IL1B +3953C>T [rs1143634]、IL1B -511C>T [rs16944]）在 100 名早产妇女和 100 名至少有一次无并发症足月妊娠且无早产史的健康妇女中的等位基因分布。
发现 IL1B +3953C>T 多态性与早产之间存在显著关联（p=0.049，OR 0.6 [0.3-1.0]）。IL1B -511C>T 多态性与早产之间无显著关联（p=0.471，OR 1.3 [0.7-2.3]）。
我们的研究结果表明，IL1B +3953C>T 多态性与白人妇女早产风险降低相关，可能通过改变妊娠期间的炎症反应。
