阳离子聚合物及其治疗潜力。
Cationic polymers and their therapeutic potential.
机构信息
Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, B-9000 Ghent, Belgium.
出版信息
Chem Soc Rev. 2012 Nov 7;41(21):7147-94. doi: 10.1039/c2cs35094g. Epub 2012 Aug 10.
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.
过去十年，人们对阳离子聚合物进行了大量研究。阳离子聚合物因其具有灵活的性质、易于合成、稳健性和已被证实的基因传递效率，成为非病毒基因传递系统的研究热点。本文综述了阳离子聚合物及其衍生物在基因传递以及各种替代治疗应用方面的最新科学进展。本文概述了阳离子聚合物的合成和制备，以及它们固有的生物活性和内在治疗潜力。此外，本文还介绍了基于阳离子聚合物的生物医学材料。本文总结了在药物和基因传递以及组织工程应用领域的主要进展。
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