Department of Pediatrics, School of Medicine, University of California, Irvine, Calif., USA.
Am J Psychiatry. 2012 Sep;169(9):907-15. doi: 10.1176/appi.ajp.2012.11091347.
Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.
生命早期的母体感觉信号在塑造发育中大脑的结构和功能方面发挥着关键作用,影响着后代对情绪和认知障碍的易感性或抵抗力。在早期生活应激的啮齿动物模型中,母体感觉信号的碎片化和不可预测性会引发后代持续的认知和情绪功能障碍。在人类妊娠和产后早期生活中,类似的母体信号的可变性和不一致性可能会影响情绪和认知功能的发展,包括那些与后来的抑郁和焦虑有关的功能。