Center for Translational Medicine Research and Development, Shen Zhen Institute of Advanced Technology, Chinese Academy of Science, Shen Zhen, Guangdong 518055, China.
Clin Rheumatol. 2013 Feb;32(2):161-5. doi: 10.1007/s10067-012-2041-1. Epub 2012 Aug 11.
At present, rheumatoid arthritis (RA) is considered a type of autoimmune disease. Its pathology is not certain, and effective drugs with less toxicity have not been established. The establishment and application of animal models are effective methods for RA research, especially using animal models similar to humans. Arthritis is more heterogeneous, and this is an important starting point when discussing animal models for arthritis. Animal models are instrumental in understanding the etiology and pathogenetic mechanisms of RA. Appropriate animal models should be selected according to experiments because they have different traits. Various methods have been applied to induce arthritis in animal experimental models, which have provided important insights into the etiopathogenetic mechanisms of human RA. This review was written to give a broad introduction of the current stage of RA model and hope to offer beneficial help for RA-related research.
目前，类风湿关节炎（RA）被认为是一种自身免疫性疾病。其病理尚不确定，尚未建立具有较少毒性的有效药物。建立和应用动物模型是 RA 研究的有效方法，特别是使用与人相似的动物模型。关节炎更具异质性，这是讨论关节炎动物模型的重要起点。动物模型有助于了解 RA 的病因和发病机制。应根据实验选择合适的动物模型，因为它们具有不同的特点。各种方法已应用于诱导动物实验模型中的关节炎，这为了解人类 RA 的病因发病机制提供了重要线索。本文旨在广泛介绍 RA 模型的现状，希望为 RA 相关研究提供有益帮助。
