Irish Separation Science Cluster, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
Proteomics. 2012 Oct;12(19-20):2904-17. doi: 10.1002/pmic.201200142. Epub 2012 Aug 29.
Polymer monolithic materials have found particularly utility in the field of bioanalysis, particularly in the area of separation science, for both enrichment and trapping of biomolecules and their analytical/preparative separations. Nanoparticle-modified monoliths have recently emerged as a new class of substrate, with unique characteristics and structure, and with selectively tailored surface chemistries for target molecules. Although several reviews exist on the applications of nanoparticles in analytical science, this review is the first to specifically summarise the applications in bioanalysis of nanoparticle-modified polymer monolithic materials. The review covers the range of nanoparticles being utilised in this way, their specific applications and future trends.
聚合物整体材料在生物分析领域，特别是在分离科学领域，具有特别的用途，可用于生物分子的富集和捕获，以及它们的分析/制备分离。纳米粒子修饰的整体材料最近作为一种新型基质出现，具有独特的特性和结构，以及针对目标分子的选择性定制表面化学。虽然有几篇关于纳米粒子在分析科学中的应用的综述，但这篇综述是第一篇专门总结纳米粒子修饰的聚合物整体材料在生物分析中的应用的综述。该综述涵盖了目前正在以这种方式使用的各种纳米粒子，以及它们的具体应用和未来趋势。
