信号通路对 mRNA 翻译的调控。
Regulation of mRNA translation by signaling pathways.
机构信息
Institute for Research in Immunology and Cancer, Université de Montréal, Québec, Canada.
出版信息
Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11):a012252. doi: 10.1101/cshperspect.a012252.
Abstract
mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of components of the translational machinery. In this work we focus on the phosphoinositide 3-kinase (PI3K)/AKT and the mitogen-activated protein kinase (MAPK) pathways, as they are strongly implicated in the regulation of translation in homeostasis, whereas their malfunction has been linked to aberrant translation in human diseases, including cancer.
摘要
mRNA 翻译是细胞中最耗能的过程。此外，它在基因表达的控制中起着关键作用，因此受到严格的调节。为了响应各种细胞外刺激和细胞内信号，信号通路通过调节翻译机制成分的磷酸化状态和活性来诱导 mRNA 翻译的定量和定性变化。在这项工作中，我们重点关注磷酸肌醇 3-激酶（PI3K）/AKT 和丝裂原活化蛋白激酶（MAPK）途径，因为它们在维持翻译的调节中具有重要作用，而它们的功能障碍与人类疾病中的异常翻译有关，包括癌症。
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