Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Endocrinol. 2012;2012:785247. doi: 10.1155/2012/785247. Epub 2012 Jul 24.
We aimed to investigate whether oral administration of captopril modulate wound healing, nitric oxide (NO), and vascular endothelial growth factor (VEGF) concentration in wound fluid of diabetic rats. 48 male Sprague-Dawley rats were divided in four groups (n = 12). The 36 rats were rendered diabetic by streptozotocin. The animals of the first and second groups received 25 and 50 mg/kg/day captopril, respectively, (DM-cap25 and DM-cap50). The animals of the third group were treated by distilled water (DM-control). Control rats had no intervention. The wound fluid level of NO and VEGF were measured. Wound specimens were investigated histopathologically. At the 5th day, there was significantly more NO(x) in wound fluid of DM-cap25 compared to other groups. At the 7th day, both captopril-treated groups had more NO(x) in wound fluid compared to other groups. At the 11th day, both captopril-treated groups had more NO(x) in wound fluid compared to DM-control group. VEGF concentration was significantly higher in both captopril-treated groups versus DM-control group (P < .05). There were significant higher wound healing scores in captopril-treated groups compared with DM-control group (P < .05). These results suggest that captopril might be useful in diabetic wound healing.
我们旨在研究卡托普利口服是否能调节糖尿病大鼠伤口愈合、伤口液中的一氧化氮（NO）和血管内皮生长因子（VEGF）浓度。48 只雄性 Sprague-Dawley 大鼠被分为四组（n = 12）。36 只大鼠通过链脲佐菌素被制成糖尿病大鼠。第一组和第二组的动物分别接受 25 和 50mg/kg/天的卡托普利（DM-cap25 和 DM-cap50）。第三组的动物用蒸馏水（DM-control）治疗。对照组大鼠没有接受干预。测量伤口液中的 NO 和 VEGF 水平。对伤口标本进行组织病理学检查。在第 5 天，DM-cap25 组伤口液中的 NO(x)明显多于其他组。在第 7 天，与其他组相比，两治疗组的伤口液中 NO(x)都更多。在第 11 天，与 DM-control 组相比，两治疗组的伤口液中 NO(x)都更多。与 DM-control 组相比，两治疗组的 VEGF 浓度明显更高（P <.05）。与 DM-control 组相比，两治疗组的伤口愈合评分明显更高（P <.05）。这些结果表明，卡托普利可能对糖尿病伤口愈合有益。
