Gimble J M
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Street, Oklahoma City 73104.
New Biol. 1990 Apr;2(4):304-12.
The fibroblasts and adipocytes of the bone marrow stroma provide the cytokines and extracellular matrix proteins required for the maturation and proliferation of the circulating blood cells. Due to the complexity of the bone marrow as an organ, the normal physiology of these stromal cells is not well understood. In particular, the role of adipocytes in the bone marrow remains controversial. Cloned bone marrow stromal cell lines provide an in vitro model for analysis of the lympho-hematopoietic microenvironment. These cells may be capable of multiple differentiation pathways, assuming the phenotype of adipocytes, chondrocytes, myocytes, and osteocytes in vitro. Characterization of these cell lines and recent in vivo experiments give new insight into the normal physiology of the bone marrow.
骨髓基质中的成纤维细胞和脂肪细胞为循环血细胞的成熟和增殖提供所需的细胞因子和细胞外基质蛋白。由于骨髓作为一个器官的复杂性，这些基质细胞的正常生理学尚未得到充分了解。特别是，脂肪细胞在骨髓中的作用仍存在争议。克隆的骨髓基质细胞系为分析淋巴细胞生成微环境提供了一个体外模型。这些细胞可能具有多种分化途径，在体外可呈现脂肪细胞、软骨细胞、肌细胞和骨细胞的表型。对这些细胞系的特性描述以及最近的体内实验为骨髓的正常生理学提供了新的见解。
