亨廷顿舞蹈症患者血液中的氧化应激和炎症生物标志物
Oxidative stress and inflammation biomarkers in the blood of patients with Huntington's disease.
作者信息
Sánchez-López Fernando, Tasset Inmaculada, Agüera Eduardo, Feijóo Montserrat, Fernández-Bolaños Ricardo, Sánchez Francisco M, Ruiz María C, Cruz Antonio H, Gascón Félix, Túnez Isaac
机构信息
Servicio de Neurología, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía de Córdoba, Córdoba, España.
出版信息
Neurol Res. 2012 Sep;34(7):721-4. doi: 10.1179/1743132812Y.0000000073.
OBJECTIVES
Huntington's disease (HD) is a neurodegenerative disorder for which there is no effective treatment. Oxidative stress and inflammation are known to be involved in HD, but the precise relationship between the two remains unclear. The aim of this study was to analyze oxidative stress and inflammation biomarkers in blood of patients with HD with a view to identifying potential links between them.
METHODS
Blood samples were collected from 13 patients with HD and from 10 age- and sex-matched controls, and the following were measured: C-reactive proteins, myeloperoxidase (MPO)/white blood cell (WBC) ratio, interleukin-6 (IL-6), thioredoxin reductase-1 (TrRd-1), thioredoxin-1 (Trx-1), total nitrites (NOx), nitric oxide synthase (NOS) and nitrotyrosine.
RESULTS
Results showed that HD is associated to a reduction of TrRd-1 and Trx-1 levels in plasma and erythrocytes, and with an increase in the MPO/WBC ratio. A positive correlation was observed between global oxidative stress (GOS) and MPO/WBC. No changes were found in NOS and Nox levels with respect to controls.
CONCLUSION
Oxidative damage may be linked to the inflammatory response in HD, via a peripheral immune response.
目的
亨廷顿舞蹈症（HD）是一种尚无有效治疗方法的神经退行性疾病。已知氧化应激和炎症与HD有关，但二者的确切关系仍不清楚。本研究旨在分析HD患者血液中的氧化应激和炎症生物标志物，以确定它们之间的潜在联系。
方法
采集13例HD患者及10例年龄和性别匹配的对照者的血样，检测以下指标：C反应蛋白、髓过氧化物酶（MPO）/白细胞（WBC）比值、白细胞介素-6（IL-6）、硫氧还蛋白还原酶-1（TrRd-1）、硫氧还蛋白-1（Trx-1）、总亚硝酸盐（NOx）、一氧化氮合酶（NOS）和硝基酪氨酸。
结果
结果显示，HD与血浆和红细胞中TrRd-1和Trx-1水平降低以及MPO/WBC比值升高有关。总体氧化应激（GOS）与MPO/WBC之间呈正相关。与对照组相比，NOS和Nox水平未发现变化。
结论
氧化损伤可能通过外周免疫反应与HD中的炎症反应相关联。
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