School of Pharmaceutical Science, Hainan Medical University, Haikou 571101, Hainan, China.
Molecules. 2012 Aug 13;17(8):9641-51. doi: 10.3390/molecules17089641.
Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear. The present study is designed to illustrate the acute toxicity and induced organ damages of the total alkaloids as well as to determine the toxic constituents. Based on the above studies, not only was the acute toxicity determined but also hepatic toxicity was characterized by increased plasma biomarkers of ALT and AST and liver cell inflammatory infiltrate as well necrosis that was firstly observed. Significantly, deoxycalyciphylline B exhibited exactly the same hepatic toxicity so it was identified as the main toxic constituent in DC. An obvious dose-effect relationship between the toxic compound and induced hepatic injuries was also observed. Moreover, the Chinese patent drug Fengliao-Changweikang contained low levels of the toxic compound, compared with the total alkaloids. Therefore, this Chinese patent drug could be regarded to be safe in this point of view.
八角莲（DC）是中药妇炎康复胶囊的主要成分，临床上有效用于治疗肠道疾病。据记载，DC 具有轻微的毒性，这是由其提取物中的生物碱引起的。不幸的是，迄今为止，其毒性水平和有毒成分仍不清楚。本研究旨在阐明总生物碱的急性毒性和诱导的器官损伤，并确定毒性成分。基于上述研究，不仅确定了急性毒性，而且还通过增加血浆 ALT 和 AST 生物标志物以及首先观察到的肝细胞炎症浸润和坏死来表征肝毒性。值得注意的是，脱氧紫堇定 B 表现出完全相同的肝毒性，因此被鉴定为 DC 中的主要毒性成分。还观察到有毒化合物与诱导的肝损伤之间存在明显的剂量-效应关系。此外，与总生物碱相比，中药妇炎康复胶囊中含有低水平的有毒化合物。因此，从这一角度来看，这种中药是安全的。
