First reported case of azole-resistant aspergillus fumigatus due to the TR/L98H mutation in Germany.
作者信息
Rath P-M, Buchheidt D, Spiess B, Arfanis E, Buer J, Steinmann J
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):6060-1. doi: 10.1128/AAC.01017-12. Epub 2012 Aug 13.
Abstract
摘要
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Development of novel PCR assays to detect azole resistance-mediating mutations of the Aspergillus fumigatus cyp51A gene in primary clinical samples from neutropenic patients.开发新型 PCR 检测方法，以检测中性粒细胞减少症患者原发性临床样本中烟曲霉 cyp51A 基因的唑类耐药相关突变。
Antimicrob Agents Chemother. 2012 Jul;56(7):3905-10. doi: 10.1128/AAC.05902-11. Epub 2012 Apr 23.
2
High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.在接触伊曲康唑的囊性纤维化成人中，烟曲霉对唑类药物的耐药率很高。
Antimicrob Agents Chemother. 2012 Feb;56(2):869-74. doi: 10.1128/AAC.05077-11. Epub 2011 Nov 28.
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Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.在印度从携带 cyp51A 基因 TR/L98H 突变的多唑耐药烟曲霉分离株。
J Antimicrob Chemother. 2012 Feb;67(2):362-6. doi: 10.1093/jac/dkr443. Epub 2011 Oct 25.
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Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009.2007-2009 年荷兰烟曲霉唑类耐药的临床意义。
Emerg Infect Dis. 2011 Oct;17(10):1846-54. doi: 10.3201/eid1710.110226.
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Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.烟曲霉分离株中唑类耐药性主要归因于 CYP51A 基因中的 TR/L98H 突变，这是 ARTEMIS 全球监测研究的结果。
Antimicrob Agents Chemother. 2011 Sep;55(9):4465-8. doi: 10.1128/AAC.00185-11. Epub 2011 Jun 20.
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Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.从囊性纤维化患者的呼吸道样本中分离出的曲霉菌属和其他霉菌：一项以烟曲霉唑类耐药性为重点的基于实验室的研究。
J Clin Microbiol. 2011 Jun;49(6):2243-51. doi: 10.1128/JCM.00213-11. Epub 2011 Apr 20.
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Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.在法国血液恶性肿瘤患者接受治疗的队列中，烟曲霉对唑类药物的耐药率较低。
J Antimicrob Chemother. 2011 Feb;66(2):371-4. doi: 10.1093/jac/dkq450. Epub 2010 Dec 5.
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Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain.奥地利、丹麦和西班牙的唑类耐药烟曲霉和其他曲霉的环境研究。
Antimicrob Agents Chemother. 2010 Nov;54(11):4545-9. doi: 10.1128/AAC.00692-10. Epub 2010 Aug 30.
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Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.烟曲霉获得性抗真菌药物耐药性：流行病学和检测。
Med Mycol. 2011 Apr;49 Suppl 1:S90-5. doi: 10.3109/13693786.2010.508469. Epub 2010 Aug 26.
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