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In Vitro and In Vivo Activity of Luliconazole (NND-502) against Planktonic Cells and Biofilms of Azole Resistant .卢立康唑（NND-502）对唑类耐药的浮游细胞和生物被膜的体外及体内活性
J Fungi (Basel). 2022 Mar 28;8(4):350. doi: 10.3390/jof8040350.
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and aspergillosis: From basics to clinics.以及曲霉病：从基础到临床
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Comparison of Two Molecular Assays for Detection and Characterization of Triazole Resistance and Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients.两种分子检测方法用于检测和鉴定免疫功能低下患者临床分离株及原代临床样本中三唑耐药性和突变的比较
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Recent developments in the management of invasive fungal infections in patients with oncohematological diseases.血液肿瘤疾病患者侵袭性真菌感染管理的最新进展
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Prevalence and mechanism of triazole resistance in Aspergillus fumigatus in a referral chest hospital in Delhi, India and an update of the situation in Asia.印度德里一家转诊胸科医院烟曲霉中三唑耐药的患病率及机制，以及亚洲情况的最新进展
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9
Environmental isolates of azole-resistant Aspergillus fumigatus in Germany.德国环境中分离出的耐唑类烟曲霉
Antimicrob Agents Chemother. 2015 Jul;59(7):4356-9. doi: 10.1128/AAC.00100-15. Epub 2015 May 4.
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Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model.异氟康唑在烟曲霉小鼠感染模型中的药效学
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本文引用的文献

1
Development of novel PCR assays to detect azole resistance-mediating mutations of the Aspergillus fumigatus cyp51A gene in primary clinical samples from neutropenic patients.开发新型 PCR 检测方法，以检测中性粒细胞减少症患者原发性临床样本中烟曲霉 cyp51A 基因的唑类耐药相关突变。
Antimicrob Agents Chemother. 2012 Jul;56(7):3905-10. doi: 10.1128/AAC.05902-11. Epub 2012 Apr 23.
2
High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.在接触伊曲康唑的囊性纤维化成人中，烟曲霉对唑类药物的耐药率很高。
Antimicrob Agents Chemother. 2012 Feb;56(2):869-74. doi: 10.1128/AAC.05077-11. Epub 2011 Nov 28.
3
Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.在印度从携带 cyp51A 基因 TR/L98H 突变的多唑耐药烟曲霉分离株。
J Antimicrob Chemother. 2012 Feb;67(2):362-6. doi: 10.1093/jac/dkr443. Epub 2011 Oct 25.
4
Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009.2007-2009 年荷兰烟曲霉唑类耐药的临床意义。
Emerg Infect Dis. 2011 Oct;17(10):1846-54. doi: 10.3201/eid1710.110226.
5
Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.烟曲霉分离株中唑类耐药性主要归因于 CYP51A 基因中的 TR/L98H 突变，这是 ARTEMIS 全球监测研究的结果。
Antimicrob Agents Chemother. 2011 Sep;55(9):4465-8. doi: 10.1128/AAC.00185-11. Epub 2011 Jun 20.
6
Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.从囊性纤维化患者的呼吸道样本中分离出的曲霉菌属和其他霉菌：一项以烟曲霉唑类耐药性为重点的基于实验室的研究。
J Clin Microbiol. 2011 Jun;49(6):2243-51. doi: 10.1128/JCM.00213-11. Epub 2011 Apr 20.
7
Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.在法国血液恶性肿瘤患者接受治疗的队列中，烟曲霉对唑类药物的耐药率较低。
J Antimicrob Chemother. 2011 Feb;66(2):371-4. doi: 10.1093/jac/dkq450. Epub 2010 Dec 5.
8
Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain.奥地利、丹麦和西班牙的唑类耐药烟曲霉和其他曲霉的环境研究。
Antimicrob Agents Chemother. 2010 Nov;54(11):4545-9. doi: 10.1128/AAC.00692-10. Epub 2010 Aug 30.
9
Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.烟曲霉获得性抗真菌药物耐药性：流行病学和检测。
Med Mycol. 2011 Apr;49 Suppl 1:S90-5. doi: 10.3109/13693786.2010.508469. Epub 2010 Aug 26.
10
Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?烟曲霉中的唑类抗性：环境中使用杀菌剂的副作用？
Lancet Infect Dis. 2009 Dec;9(12):789-95. doi: 10.1016/S1473-3099(09)70265-8.

First reported case of azole-resistant aspergillus fumigatus due to the TR/L98H mutation in Germany.

作者信息

Rath P-M, Buchheidt D, Spiess B, Arfanis E, Buer J, Steinmann J

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):6060-1. doi: 10.1128/AAC.01017-12. Epub 2012 Aug 13.

DOI:10.1128/AAC.01017-12
PMID:22890769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486539/
Abstract
摘要