[Separate and combined effects of ionizing radiation and cyclophosphamide on thymus-dependent humoral immune response].

The total exposure of gamma-irradiation, (1-2 Gy) or intraperitoneally injection of cyclophosphamide (10-50 mg/kg) resulted in the dose-dependent inhibition of humoral immune response. The immunosuppression was expressed to a greater degree in lymphatic nodules, than in spleen. The combined action of these factors showed the effect of synergism. The injection of cyclophosphamide in mice neutralized the effect of antibody genesis induced by low dose irradiation (0.1 Gy).