Sharetskiĭ A N, Surinov B P, Abramova M R
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
Radiats Biol Radioecol. 1998 Sep-Oct;38(5):696-700.
The total exposure of gamma-irradiation, (1-2 Gy) or intraperitoneally injection of cyclophosphamide (10-50 mg/kg) resulted in the dose-dependent inhibition of humoral immune response. The immunosuppression was expressed to a greater degree in lymphatic nodules, than in spleen. The combined action of these factors showed the effect of synergism. The injection of cyclophosphamide in mice neutralized the effect of antibody genesis induced by low dose irradiation (0.1 Gy).
γ射线照射（1 - 2 Gy）或腹腔注射环磷酰胺（10 - 50 mg/kg）的总暴露量导致体液免疫反应呈剂量依赖性抑制。免疫抑制在淋巴小结中比在脾脏中表现得更为明显。这些因素的联合作用显示出协同效应。给小鼠注射环磷酰胺可中和低剂量照射（0.1 Gy）诱导的抗体产生效应。
