Department of Geriatrics, Chongqing Medical University, Chongqing, China.
CNS Spectr. 2012 Sep;17(3):142-54. doi: 10.1017/S1092852912000533. Epub 2012 Aug 15.
The goal of this study was to determine the relationship between age and risk for depression among the old and the oldest old. Method MEDLINE, EMBASE, and the Cochrane Library database were used to identify potential studies. The studies were divided into cross-sectional and longitudinal subsets. For each study, the numbers of the total participants, cases (for cross-sectional study), or incident cases (for longitudinal study) of depression in each age group were extracted and entered into Review Manager 4.2 software. Qualitative meta-analyses of cross-sectional studies and of longitudinal studies were performed. For prevalence and incidence rates of depression, odds risk (OR) and relative risk (RR) were calculated, respectively.
The qualitative meta-analyses showed that, compared with younger participants (above vs. below 65 years, above vs. below 70 years, above vs. below 75 years, and above vs. below 80 years), older age groups had a significantly higher risk for depression. (All of the ORs and RRs were significant.) Compared with participants aged 55-89, those aged above 90 years had no higher risk for depression. (Neither the OR nor the RR was significant.)
Despite the methodological limitations of this meta-analysis, older age appears to be an important risk factor for depression in the general elderly population (aged below 80 years), but not in the oldest population (aged above 85 years).
本研究旨在确定老年人和高龄老人中年龄与抑郁风险之间的关系。方法：使用 MEDLINE、EMBASE 和 Cochrane 图书馆数据库来确定潜在的研究。这些研究分为横断面研究和纵向研究。对于每项研究，提取并输入到 Review Manager 4.2 软件中的是每个年龄组中总参与者、病例（对于横断面研究）或新发病例（对于纵向研究）的数量。对横断面研究和纵向研究进行定性荟萃分析。对于抑郁的患病率和发病率，分别计算了比值比（OR）和相对风险（RR）。
定性荟萃分析显示，与年轻参与者（65 岁以上、70 岁以上、75 岁以上和 80 岁以上相比）相比，年龄较大的年龄组患抑郁的风险显著更高。（所有的 OR 和 RR 均有统计学意义。）与 55-89 岁的参与者相比，年龄在 90 岁以上的参与者患抑郁的风险没有增加。（OR 和 RR 均无统计学意义。）
尽管该荟萃分析存在方法学限制，但年龄似乎是一般老年人群（<80 岁）中抑郁的重要危险因素，但在高龄人群（>85 岁）中并非如此。
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