Dhaliwal Catharine A, Torgersen Antonia, Ross Jonathan J, Ironside James W, Biswas Asok
Department of Pathology, Western General Hospital, Edinburgh, United Kingdom.
Am J Dermatopathol. 2013 Feb;35(1):117-24. doi: 10.1097/DAD.0b013e31826367be.
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade sweat gland carcinoma with a strong predilection to the eyelid region. It is histologically analogous to endocrine ductal carcinoma/solid papillary carcinoma of the breast and is characterized by a multinodular solid cystic mucinous tumor with immunoreactivity to neuroendocrine markers. Only 20 cases of this unusual tumor have been reported. We present the clinical and histopathologic findings of 2 new cases of EMPSGC and review the relevant literature. The histological differential diagnosis is discussed and attention drawn to the role of immunohistochemistry in clarifying the nosological position of EMPSGC within the spectrum of cutaneous mucinous neoplasms.
内分泌黏液生成性汗腺癌（EMPSGC）是一种罕见的低级别汗腺癌，极易发生于眼睑部位。其在组织学上类似于乳腺内分泌导管癌/实性乳头状癌，特征为多结节实性囊性黏液性肿瘤，对神经内分泌标志物具有免疫反应性。目前仅报道了20例这种罕见肿瘤。我们报告了2例EMPSGC新病例的临床和组织病理学发现，并复习了相关文献。文中讨论了组织学鉴别诊断，并强调了免疫组化在明确EMPSGC在皮肤黏液性肿瘤谱系中的分类学地位方面的作用。
