Brett Mary Anne, Salama Samih, Gohla Gabriella, Alowami Salem
St. Joseph's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
Case Rep Pathol. 2017;2017:6343709. doi: 10.1155/2017/6343709. Epub 2017 Feb 19.
Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare adnexal tumor of the skin with low-grade cytological features and neuroendocrine differentiation. It has a predilection for the skin of the eyelid, but has also been reported in the face and rarely extra-facial locations. The tumor is seen more frequently in women and on average affects the elderly. It is histologically and immunohistochemically analogous to solid papillary carcinoma of the breast/endocrine ductal carcinoma in situ with a nodular, solid, papillary, and/or cribriforming architecture, neuroendocrine differentiation, and mucin production. Since it was first described by Flieder et al. in 1997, less than 60 cases have been reported in literature. We describe the morphological and immunohistochemical features of another case with a review of the common histological differential diagnoses and emphasize the salient features that help distinguish this rare neoplasm.
内分泌黏液生成性汗腺癌（EMPSGC）是一种罕见的皮肤附属器肿瘤，具有低级别细胞学特征和神经内分泌分化。它好发于眼睑皮肤，但也有在面部以及极少的面部以外部位的报道。该肿瘤在女性中更常见，平均发病年龄为老年人。在组织学和免疫组化方面，它类似于乳腺实性乳头状癌/原位内分泌导管癌，具有结节状、实性、乳头状和/或筛状结构、神经内分泌分化以及黏液生成。自1997年Flieder等人首次描述以来，文献报道的病例不到60例。我们描述了另一例病例的形态学和免疫组化特征，并回顾了常见的组织学鉴别诊断，强调了有助于鉴别这种罕见肿瘤的显著特征。
