Department of Restorative Odontology and Endodontics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
J Endod. 2012 Sep;38(9):1187-91. doi: 10.1016/j.joen.2012.06.009. Epub 2012 Jul 10.
The skin microcirculation is significantly affected by serum estrogen levels. The objective of this study was to investigate the effects of estrogen serum level changes associated with the menstrual cycle and postmenopause on dental pulp blood flow (PBF) as well as its dynamics.
Young women at the menstrual phase (low serum estrogen levels) and in the mid-cycle phase of the menstrual cycle (high serum estrogen levels) and postmenopausal women were enrolled in the study. PBF and its oscillations were measured by laser Doppler flowmetry and analyzed by using wavelet transform. Serum levels of estradiol-17β were measured by immunoassay.
PBFs of young women in the menstrual phase and postmenopausal women were mutually similar and significantly lower than those of young women in the mid-cycle period. With respect to the mid-cycle phase, relative amplitude and power were significantly increased in the interval 0.0095-0.02 Hz and decreased in the intervals 0.02-0.06 and 0.06-0.2 Hz in the menstrual phase. A significant decrease in 0.0095-0.02 Hz and increase in 0.02-0.06, 0.06-0.2, 0.2-0.6, and 0.6-1.6 Hz intervals were observed in postmenopause.
The study has shown that the menstrual phase of the menstrual cycle and postmenopause have similar PBF decrease, but PBF oscillations are differently affected in the mid-cycle phase.
血清雌激素水平对皮肤微循环有显著影响。本研究旨在探讨与月经周期和绝经后相关的血清雌激素水平变化对牙髓血流（PBF）及其动力学的影响。
招募处于月经期（血清雌激素水平低）和月经周期中期（血清雌激素水平高）的年轻女性以及绝经后女性。采用激光多普勒血流仪测量 PBF 及其波动，并采用小波变换进行分析。采用免疫测定法测量雌二醇-17β的血清水平。
月经期年轻女性和绝经后女性的 PBF 相互相似，且明显低于月经中期的年轻女性。与月经中期相比，月经期的相对幅度和功率在 0.0095-0.02 Hz 间隔内显著增加，而在 0.02-0.06 和 0.06-0.2 Hz 间隔内则显著降低。绝经后，0.0095-0.02 Hz 间隔明显降低，0.02-0.06、0.06-0.2、0.2-0.6 和 0.6-1.6 Hz 间隔则明显增加。
本研究表明，月经周期的月经期和绝经后具有相似的 PBF 降低，但月经中期 PBF 波动受到不同的影响。
