Pires Carla Andréa Avelar, Xavier Marilia Brasil, Quaresma Juarez Antônio Simões, Macedo Geraldo Mariano Moraes de, Sousa Bruna Ranyelle de Marinho, Brito Arival Cardoso de
Federal University of Pará, Belem, Brazil.
An Bras Dermatol. 2012 Jul-Aug;87(4):555-60. doi: 10.1590/s0365-05962012000400006.
Chromoblastomycosis is a chronic fungal infection caused by fungi from the Dematiaceae family. According to several studies, Fonsecaea pedrosoi is the most common of these fungi. The infection is more common in tropical countries, with the Brazilian state of Pará having one of the largest infected populations worldwide. The disease is difficult to treat and recurrences are common.
To describe the epidemiological and mycological aspects of cases of chromoblastomycosis and its clinical forms in the state of Pará, Brazil.
Mycological exams (direct mycological examinations, culture and microculture) were performed and a clinical/epidemiological evaluation was made of 65 patients receiving care at the Dermatology Department of the Federal University of Pará between 2000 and 2007. The clinical classification proposed by Carrión in 1950 was used in this study.
The majority of the patients were male (93.8%), agricultural workers (89.2%) of 45 to 55 years of age, and the majority of lesions (55.4%) were of the verrucous type, located principally on the lower limbs (81.5%). In the majority of the cases investigated (61.5%), the infection had been present for a long time, with a mean duration of 11 years. Direct mycological examination was performed in 86.2% of the patients (n=56). Of these, 96.4% (n=54) tested positive. Culture and microculture were performed in vitro in 47 cases of those that tested positive at direct microscopy, results showing Fonsecaea pedrosoi to be the only agent present in this sample.
This study highlighted the extent to which chromoblastomycosis still affects the quality of life of the local population, principally individuals working in agriculture. This is a chronic disease for which there is no effective treatment. The importance of continuing to investigate this disease should be emphasized, as further studies may lead to new clinical or epidemiological findings.
着色芽生菌病是一种由暗色孢科真菌引起的慢性真菌感染。根据多项研究，裴氏着色霉是这些真菌中最常见的一种。这种感染在热带国家更为常见，巴西帕拉州是全球感染人数最多的地区之一。该病难以治疗且复发常见。
描述巴西帕拉州着色芽生菌病病例的流行病学和真菌学特征及其临床类型。
对2000年至2007年期间在帕拉联邦大学皮肤科接受治疗的65例患者进行真菌学检查（直接真菌学检查、培养和微量培养），并进行临床/流行病学评估。本研究采用了卡里翁于1950年提出的临床分类方法。
大多数患者为男性（93.8%），年龄在45至55岁之间的农业工人（89.2%），大多数皮损（55.4%）为疣状类型，主要位于下肢（81.5%）。在大多数调查病例（61.5%）中，感染已存在很长时间，平均病程为11年。86.2%的患者（n = 56）进行了直接真菌学检查。其中，96.4%（n = 54）检测呈阳性。在直接显微镜检查呈阳性的47例病例中进行了体外培养和微量培养，结果显示裴氏着色霉是该样本中唯一存在的病原体。
本研究突出了着色芽生菌病对当地居民生活质量的影响程度，主要是从事农业的人群。这是一种尚无有效治疗方法的慢性病。应强调继续研究这种疾病的重要性，因为进一步的研究可能会带来新的临床或流行病学发现。
