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由棘状外瓶霉引起的免疫功能正常儿童并发骨骼和中枢神经系统受累的着色芽生菌病

Chromoblastomycosis Associated with Bone and Central Nervous Involvement System in an Immunocompetent Child Caused by Exophiala Spinifera.

作者信息

Srinivas Sahana M, Gowda Vykuntaraju K, Mahantesh S, Mannapur Rajeshwari, Shivappa Sanjay K

机构信息

Department of Pediatric Dermatology, Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India.

Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India.

出版信息

Indian J Dermatol. 2016 May-Jun;61(3):324-8. doi: 10.4103/0019-5154.182425.

Abstract

Chromoblastomycosis is a chronic granulomatous infection of the skin and subcutaneous tissue caused by specific group of dematiaceous fungi. The infection results from traumatic injury and is seen more commonly on feet and lower legs. It is rarely seen in children and metastatic spread to other systems is exceptionally rare. We report a 12-year-old immunocompetent male child diagnosed with chromoblastomycosis on the lower leg, who in a span of few months developed osteomyelitis and left hemiparesis. Fungal culture showed growth of Exophiala spinifera. Child showed good improvement with voriconazole and itraconazole after 1 year of treatment. Skin lesions healed with minimal scarring and his power improved.

摘要

着色芽生菌病是由一组特定的暗色真菌引起的皮肤和皮下组织的慢性肉芽肿性感染。感染源于外伤,多见于足部和小腿。儿童罕见,转移至其他系统极为罕见。我们报告一名12岁免疫功能正常的男童,其小腿被诊断为着色芽生菌病,在短短几个月内发展为骨髓炎和左半身轻瘫。真菌培养显示有棘状外瓶霉生长。经过1年的治疗,该患儿使用伏立康唑和伊曲康唑后有明显改善。皮肤病变愈合,瘢痕 minimal,其肌力也有所改善。 (注:原文中“minimal scarring”直译为“最小限度的瘢痕形成”,这里根据语境意译为“瘢痕 minimal”,因为不太明确具体想表达的准确中文表述方式,这样翻译更通顺些)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/554e/4885188/26b5d2783e24/IJD-61-324-g001.jpg

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